ReviewEating and weight disorders : EWD2021
Obesity paradox and stroke: a narrative review.
Review in Eating and weight disorders : EWD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Effect of semaglutide on arrhythmic, major cardiovascular, and renal outcomes in patients with overweight or obesity: a systematic review and meta-analysis.European journal of medical research · 2025 · on this mapPooled it
- Efficacy of Baduanjin for obesity and overweight: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- A novel nomogram to predict mortality in patients with stroke: a survival analysis based on the MIMIC-III clinical database.BMC medical informatics and decision making · 2022Trial
- Association of obesity and nutritional status on early sepsis-associated acute kidney injury in older patients with sepsis.BMC nephrology · 2026Article
- The impact of BMI on mechanical thrombectomy outcomes, insights from a comprehensive stroke center.Neurosurgical review · 2026Article
- Effects of Undernutrition and Obesity on Functional and Nutritional Outcomes After Ischaemic Stroke: A Hospital-Based Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Article
- The interaction between lifestyle and blood pressure on Stroke: A cross-sectional study from Northern China.PloS one · 2026Article
- Impact of lean body mass index on short-term outcomes in patients with ischemic stroke: an observational cohort study.Scientific reports · 2025Observational
- Both body roundness index and the body mass index increase the prevalence of stroke but reduce the risk of all-cause mortality.Journal of health, population, and nutrition · 2025Article
- Total bilirubin modifies the relationship between obesity and stroke.Diabetology & metabolic syndrome · 2025Article
- Evaluating the obesity paradox in patients with sepsis and cancer.International journal of obesity (2005) · 2025Article
- Sex-Specific Adaptations in Alzheimer's Disease and Ischemic Stroke: A Longitudinal Study in Male and Female APPLife (Basel, Switzerland) · 2025Article
- The association between android-to-gynoid lean mass ratio and all-cause and specific-cause mortality in US adults: A prospective study.Diabetes, obesity & metabolism · 2025Article
- Joint association of triglyceride glucose index (TyG) and a body shape index (ABSI) with stroke incidence: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- Evaluating machine learning models for stroke prediction based on clinical variables.Frontiers in neurology · 2025Article
- Hypertension mediates the association between weight-adjusted waist index and new onset stroke risk in middle-aged and older Chinese adults: evidence from the CHARLS study.Frontiers in neurology · 2025Article
- Impact of body composition on pathological response to neoadjuvant immunotherapy in dMMR/MSI-H colorectal cancer.Frontiers in immunology · 2025Article
- Predictors of poor outcomes in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- Association between BMI-based metabolic phenotypes and prevalence of intracranial atherosclerotic stenosis: a cross-sectional study.International journal of obesity (2005) · 2024Article
- Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite obesity is an established risk factor for stroke, several studies reported a better outcome after stroke in obese and overweight patients. This counterintuitive finding, which was described in the whole spectrum of cardiovascular diseases, is known as obesity paradox.
objectiveThis is a narrative overview on the obesity paradox and stroke.
methodsWe used as sources MEDLINE/PubMed, CINAHL, EMBASE, and Cochrane Library from inception to 2019, and selected papers that discussed the association of obesity with outcome and mortality after stroke.
resultsThe majority of studies reported lower mortality rates and better functional outcome after stroke in obese and overweight patients compared with normal weight and underweight patients, suggesting the existence of an obesity paradox in stroke. However, available studies are limited by several major methodological concerns including absence of randomized trials, retrospective nature of most studies, assessment of obesity with body mass index (BMI), non-linear relationship between BMI and outcome, short follow-up period, and differences in co-morbid conditions and stroke characteristics.
conclusionsThe existence of an obesity paradox in stroke is still controversial and further higher quality evidence is needed to clarify the relationship between obesity and stroke outcome. LEVEL OF EVIDENCE: Level V, narrative review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.