ArticleCognitive, affective & behavioral neuroscience2020
Functional connectivity of the anterior insula associated with intolerance of uncertainty in youth.
Article in Cognitive, affective & behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions.Developmental cognitive neuroscience · 2024Pooled it
- The impact of an app-delivered mindfulness-based intervention on resting-state functional connectivity in pediatric concussion: a pilot study.Frontiers in neuroscience · 2026Trial
- Why are you looking at me like that? Intolerance of uncertainty and emotional face processing in social anxiety disorder.NeuroImage. Clinical · 2026Article
- The role of dorsal anterior cingulate cortex in dynamic attitude changes in naturalistic settings.Communications biology · 2026Article
- Cerebellar and subcortical interplay in cognitive dysmetria: functional network signatures associate with symptom and trait assessments across schizophrenia, bipolar II, and ADHD patients.Brain imaging and behavior · 2025Article
- Distinct Topological Properties of the Reward Anticipation Network in Preadolescent Children With Binge Eating Disorder Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.Human brain mapping · 2023Article
- Insula-cingulate structural and functional connectivity: an ultra-high field MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Active Inference, Epistemic Value, and Uncertainty in Conceptual Disorganization in First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- Brain regions associated with olfactory dysfunction in first episode psychosis patients.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- Visualizing risky situations induces a stronger neural response in brain areas associated with mental imagery and emotions than visualizing non-risky situations.Frontiers in human neuroscience · 2023Article
- Intolerance of uncertainty and functional connectivity of the anterior insula during anticipation of unpredictable reward.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Disentangling predictive processing in the brain: a meta-analytic study in favour of a predictive network.Scientific reports · 2021Article
- Towards a model of uncertainty distress in the context of Coronavirus (COVID-19).Cognitive behaviour therapist · 2020Review
- Neuroimaging alterations and relapse in early-stage psychosis.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Intolerance of uncertainty (IU) is a trait characteristic marked by distress in the face of insufficient information. Elevated IU has been implicated in the development and maintenance of anxiety disorders, particularly during adolescence, which is characterized by dramatic neural maturation and the onset of anxiety disorders. Previous task-based work implicates the bilateral anterior insula in IU. However, the association between anterior insula intrinsic functional connectivity (iFC) and IU has not been examined in adolescents. Fifty-eight healthy youth (mean age = 12.56; 55% boys) completed the Intolerance of Uncertainty Scale for Children (IUSC-12) and a 6-minute resting state fMRI scan. Group-level analyses were conducted using a random-effects, ordinary least-squares model, including IUSC-12 scores (Total, Inhibitory subscale, Prospective subscale), and three nuisance covariates (age, sex, and mean framewise displacement). IUSC-12 Inhibitory subscale scores were predictive of iFC between the left and right anterior insula and right prefrontal regions. IUSC-12 Prospective subscale scores significantly predicted iFC between the anterior insula and the anterior cingulate cortex. IUSC-12 total scores did not predict significant iFC of the bilateral anterior insula. Follow-up analyses, including anxiety (MASC Total Score) in the models, failed to find significant results. This could suggest that the associations found between IUSC-12 scores and anterior insula iFC are not unique to IU and, rather, reflect a broader anxiety-related connectivity pattern. Further studies with larger samples are needed to tease apart unique associations. These findings bear significance in contributing to the literature evaluating the neural correlates of risk factors for anxiety in youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.