ArticleDermatology and therapy2020
Neuroimaging Features, Follow-Up Analyses, and Comparisons Between Asymptomatic and Symptomatic Neurosyphilis.
Article in Dermatology and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Neurosyphilis in China: A Systematic Review of Cases From 2009-2021.Frontiers in medicine · 2022Pooled it
- Prognostic predictors in HIV-negative neurosyphilis: a retrospective cohort study with prospective follow-up.BMC infectious diseases · 2026Article
- Neurosyphilis with simultaneous brain and spinal cord involvement mimicking intracranial tumors: a case report.BMC neurology · 2026Article
- Research progress on the mechanisms of neurosyphilis' impact on cognitive function, early identification, and prevention strategies.Frontiers in neurology · 2025Review
- Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis.European journal of medical research · 2024Article
- Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report.World journal of clinical cases · 2024Article
- Hippocampal region metabolites and cognitive impairment in patients with general paresis: based onFrontiers in pharmacology · 2024Article
- MRI of neurosyphilis with mesiotemporal lobe lesions of "knife-cut sign" on MRI: A case report and literature review.Heliyon · 2023Article
- Neurosyphilis: The Great Imitator.Cureus · 2022Article
- Article
- Neurosyphilis with a rare magnetic resonance imaging pattern confirmed by metagenomic next-generation sequencing: a case report.European journal of medical research · 2022Article
- An Updated Review of Recent Advances in Neurosyphilis.Frontiers in medicine · 2022Review
- Neurosyphilis with ocular involvement and normal magnetic resonance imaging results affirmed by metagenomic next-generation sequencing.Frontiers in cellular and infection microbiology · 2022Review
- Asymptomatic neurosyphilis may need early intervention in people living with HIV.Chinese medical journal · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMany studies have explored the imaging characteristics of patients with neurosyphilis, but no systematic study has been made on the neuroimaging changes after anti-syphilitic treatment. The purpose of this study was to examine neuroimaging differences before and after treatment, comparing patients with asymptomatic and symptomatic neurosyphilis.
methodsA total of 102 patients with neurosyphilis, including 60 cases of symptomatic neurosyphilis and 42 cases of asymptomatic neurosyphilis, were identified between December 2012 and June 2019. Their demographics, medical histories, serological tests of peripheral blood and cerebrospinal fluid, and especially neuroimaging features before and after anti-syphilitic treatment were collected and analyzed.
resultsThe patients presented with variable clinical and neuroimaging features, including cerebral infarction or hemorrhage, atrophy, demyelination, arteritis, encephalitis, and hippocampal sclerosis. A total of 29 neuroradiological re-examinations were performed in 19 patients treated with anti-syphilitic medicine. The results indicated that some patients still presented neuroradiological progression after treatment, including 42.1% showing infarction lesions, 47.4% mild to severe brain atrophy, and 15.8% white matter demyelination.
conclusionThe clinical and neuroimaging features of neurosyphilis patients are diverse, and their follow-up neuroimaging continued to show progression even with standardized treatment.
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