Evidence map›Paper›PMID 32124189›Full record

ReviewCurrent HIV/AIDS reports2020

The Impact of Treatment as Prevention on the HIV Epidemic in British Columbia, Canada.

Viviane D Lima, Zabrina L Brumme, Chanson Brumme, Paul Sereda, Mel Krajden, Jason Wong, Silvia A Guillemi, Bonnie Henry, Robert S Hogg, Rolando Barrios and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Viviane D LimaBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Zabrina L BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Chanson BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Paul SeredaBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Mel KrajdenBritish Columbia Centre for Disease Control, Vancouver, Canada.
Jason WongBritish Columbia Centre for Disease Control, Vancouver, Canada.
Silvia A GuillemiBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Bonnie HenryBritish Columbia Ministry of Health, Victoria, Canada.
Robert S HoggBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Rolando BarriosBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada.
Julio S G MontanerBritish Columbia Centre for Excellence in HIV/AIDS, Room 667, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada. jmontaner@cfenet.ubc.ca.
STOP HIV/AIDS Study Group
University of British Columbia · CAMinistry of Health · CASimon Fraser University · CAAIDS Vancouver · CABC Centre for Disease Control · CAUniversity of British Columbia Hospital · CAVancouver Coastal Health · CA

Funding

Seek and Treat for Optimal Prevention of HIV & AIDS (STOP HIV/AIDS) in BCR01DA036307 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI MONTANER, JULIO SERGIO GONZALEZ · 2013 to 2017
$3.0M
CIHRNIDA NIH HHS R01 DA036307
6 · The paper itself

Abstract

purpose of reviewThis study proposes to describe the impact of a publicly funded Treatment as Prevention (TasP) strategy in British Columbia (BC), Canada, in decreasing the individual and public health impact of the HIV/AIDS Epidemic. RECENT

findingsIn BC, TasP has been associated with a steady decline in HIV-related morbidity and mortality. At the same time, a demographic transition was observed among people living with HIV (PLWH), with the majority of those on antiretroviral treatment (ART) now ≥ 50 years of age, living with at least one comorbidity, and dying from age-associated comorbidities. We also documented a progressive increase in the proportion of viral load suppression as a result of ART expansion. While the pre-ART CD4 T cell count has increased steadily in recent years, there is still a large proportion of PLWH being diagnosed in later stages of HIV infection. New HIV diagnoses have been rapidly declining, however to a lesser extent among men who have sex with men (MSM), and BC is currently experiencing an increase in infectious syphilis cases in this population. These facts reinforce the effectiveness of TasP in decreasing HIV transmission, but at the same time, it highlights the need for further innovation to enhance the control of HIV and syphilis among MSM. This study supports the development of new approaches that address existing gaps in the TasP strategy in BC, and the future health needs of PLWH.

Indexed as

Acquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBritish ColumbiaCD4 Lymphocyte CountFemaleGovernment ProgramsHomosexuality, MaleHumansMaleMiddle AgedPreventive Health ServicesSexual and Gender MinoritiesViral LoadAnti-Retroviral AgentsBritish ColumbiaCanadaHIV epidemicTasPTreatment as prevention

Identifiers

PMID32124189
PMCPMC8797149
OpenAlexW3009366738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.