ArticleInternational journal of clinical oncology2020
Variations in clinical features and oncologic behaviors of T1 colorectal cancer according to tumor location.
Article in International journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Differentiation grade as a risk factor for lymph node metastasis in T1 colorectal cancer.DEN open · 2024Article
- Long-term outcomes of endoscopic or surgical resection in T1 colorectal cancer patients: a retrospective cohort study.Surgical endoscopy · 2024Article
- Weighing the benefits of lymphadenectomy in early-stage colorectal cancer.Annals of surgical treatment and research · 2023Review
- CT morphological features for predicting the risk of lymph node metastasis in T1 colorectal cancer.European radiology · 2023Article
- Tumor Location as a Prognostic Factor in T1 Colorectal Cancer.Journal of the anus, rectum and colon · 2022Review
- Risk Stratification of T1 Colorectal Cancer Metastasis to Lymph Nodes: Current Status and Perspective.Gut and liver · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent genetic characteristics according to tumor location result in variations in survival rates and treatment responses in advanced colorectal cancer (CRC). However, the effects of tumor location during early CRC are still unclear.
methodsPatients with T1 CRC treated between 2003 and 2019 were enrolled from a prospectively collected database. Patients were once divided into four groups, then combined into two groups (right- and left-sided CRC) according to the tumor location, and clinical features and oncologic behaviors were compared.
resultsIn total, 458 patients were analyzed. Right-sided CRC had a lower incidence of polypoid type tumor than left-sided CRC (36/126 (28.6%) vs 186/332 (56.0%), p < 0.001). There were no differences in tumor size, pathological grade, pT1 substage and lymphovascular invasion between right- and left-sided CRC. Overall, lymph nodal involvement was observed in 42/458 (9.1%) patients. Right-sided CRC had a lower rate of patients with lymph nodal involvement than left-sided CRC (6/126 (4.8%) vs 36/332 (10.8%), p = 0.04).
conclusionThe present study revealed that there were significant differences in the macroscopic type and the incidence of lymph node involvement between right- and left-sided CRC. The clinical features and oncologic behaviors of T1 CRC are possible to vary according to tumor location.
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