ArticleJA clinical reports2020
A rare case of atropine-resistant bradycardia following sugammadex administration.
Article in JA clinical reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of sugammadex and rocuronium on electro-mechanical activity of cardiac myocytes.Korean journal of anesthesiology · 2025Article
- Review
- Kounis Syndrome: Review of Clinical Cases.Cardiovascular & hematological disorders drug targets · 2024Review
- Asystolic cardiac arrest secondary to sugammadex administration in a young patient.Anaesthesiology intensive therapy · 2024Article
- Aortic dissection type 1, windsock sign, neglected lead, and Kounis syndrome: What a coincidence!Anatolian journal of cardiology · 2021Article
- Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study.BMC anesthesiology · 2021Article
- Gadolinium-induced Kounis syndrome including electrocardiographic considerations.Proceedings (Baylor University. Medical Center) · 2020Article
- Sugammadex-induced atropine-resistant bradycardia: clinical, pathophysiologic, and electrocardiographic considerations.JA clinical reports · 2020Article
- Sugammadex-induced anaphylactic reaction: A systematic review.Journal of anaesthesiology, clinical pharmacologyReview
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundProfound bradycardia caused by sugammadex has been reported, although its mechanism is unclear. Herein, we suggest a possible culprit for this phenomenon. CASE PRESENTATION: A 50-year-old woman without comorbidity except mild obesity underwent a transabdominal hysterectomy and right salpingo-oophorectomy. After surgery, sugammadex 200 mg was intravenously administered. Approximately 4 min later, her heart rate decreased to 36 bpm accompanied by hypotension (41/20 mmHg) and ST depression in limb lead electrocardiogram (ECG). Atropine 0.5 mg was injected intravenously without improving the hemodynamics. Intravenous adrenaline 0.5 mg was added despite the lack of signs suggesting allergic reactions. Her heart rate and blood pressure quickly recovered and remained stable thereafter, although 12-lead ECG taken 1 h later still showed ST depression.
conclusionsIn this case, the significant bradycardia appeared attributable to coronary vasospasm (Kounis syndrome) induced by sugammadex, considering the ECG findings and high incidence of anaphylaxis due to sugammadex.
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