Evidence map›Paper›PMID 32124042›Full record

ArticleJournal of neurology2020

Efficacy of inpatient personalized multidisciplinary rehabilitation in multiple sclerosis: behavioural and functional imaging results.

Priska Zuber, Charidimos Tsagkas, Athina Papadopoulou, Laura Gaetano, Manuel Huerbin, Emanuel Geiter, Anna Altermatt, Katrin Parmar, Thierry Ettlin, Corina Schuster-Amft and 7 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Priska ZuberDivision of Cognitive Neuroscience, Faculty of Psychology, University of Basel, Basel, Switzerland.
Charidimos TsagkasDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland.
Athina PapadopoulouDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland.
Laura GaetanoF. Hoffman-La Roche Ltd, Basel, Switzerland.
Manuel HuerbinMedical Image Analysis Center (MIAC AG), Basel, Switzerland.
Emanuel GeiterDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland.
Anna AltermattMedical Image Analysis Center (MIAC AG), Basel, Switzerland.
Katrin ParmarDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland.
Thierry EttlinReha Rheinfelden, Rheinfelden, Switzerland.
Corina Schuster-AmftReha Rheinfelden, Rheinfelden, Switzerland.
Zorica SuicaReha Rheinfelden, Rheinfelden, Switzerland.
Hala AlrasheedDepartment of Neurology and Neurorehabilitation, Clinics of Valens, Valens, Switzerland.
Jens WuerfelMedical Image Analysis Center (MIAC AG), Basel, Switzerland.
Jürg KesselringDepartment of Neurology and Neurorehabilitation, Clinics of Valens, Valens, Switzerland.
Ludwig KapposDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland.
Till SprengerDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland.
Stefano MagonDepartment of Neurology, University Hospital Basel, Neurologic Clinic and Policlinic, Petersgraben 4, 4031, Basel, Switzerland. stefano.magon@usb.ch.ORCID http://orcid.org/0000-0003-1517-7581

Funding

Schweizerische Multiple Sklerose Gesellschaft 2015
6 · The paper itself

Abstract

backgroundAlthough multidisciplinary rehabilitation programs are commonly used in clinical practice for patients with multiple sclerosis (MS), they are currently underexamined.

objectiveThis study aims to investigate the efficacy and underlying brain mechanisms of an inpatient multidisciplinary rehabilitation.

methodsTwenty-four patients with relapse-onset MS underwent a 4-week personalized inpatient multidisciplinary rehabilitation and three assessment sessions including MRI, clinical, cognitive and motor function evaluation. Twenty-four healthy controls underwent two assessment sessions 4 weeks apart. Test performances were compared using repeated measures ANOVA, Tukey and t tests. A motor sequence learning (MSL) task was presented during fMRI and data were analysed using FSL.

resultsPatients had less perceived fatigue, improved walking speed and quality of life following the rehabilitation, which could be maintained at follow-up 4 weeks after rehabilitation. After rehabilitation, differences in accuracy of the MSL task between groups diminished, indicating an improved performance in patients. Improved accuracy went along with changes of brain activity in the left cerebellum and right frontal lobe post-rehabilitation, which could be maintained at follow-up. No changes between sessions were observed in controls.

conclusionMultidisciplinary rehabilitation may improve highly impacting symptoms through more efficient recruitment of brain regions and therefore positively influence MS patients' quality of life.

Indexed as

Neurological RehabilitationOutcome Assessment, Health CareAdultBrainEcho-Planar ImagingFemaleFunctional NeuroimagingHumansInpatientsLongitudinal StudiesMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsQuality of LifeFatiguefMRIMotor skillsMultidisciplinary rehabilitationMultiple sclerosisQuality of life

Identifiers

PMID32124042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.