Evidence map›Paper›PMID 32123839›Full record

ArticleFASEB bioAdvances2019

Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: A review.

Jun Kobayashi, Hiroyuki Uchida, Ayaka Kofuji, Junta Ito, Maki Shimizu, Hyounju Kim, Yusuke Sekiguchi, Seiji Kushibe

Open access · goldAbstract read
In one paragraph

Article in FASEB bioAdvances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

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  2. A standardized combination ofFood & nutrition research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jun KobayashiDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Hiroyuki UchidaDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Ayaka KofujiDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Junta ItoDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Maki ShimizuDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Hyounju KimDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Yusuke SekiguchiDepartment of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Science Josai University Saitama Japan.
Seiji KushibeDepartment of Management, Faculty of Management Josai University Saitama Japan.
Josai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of internal and external factors such as exercise, nutrition, inflammation, and cancer-associated cachexia affect the regulation of skeletal muscle mass. Because skeletal muscle functions as a crucial regulator of whole body metabolism, rather than just as a motor for locomotion, the enhancement and maintenance of muscle mass and function are required to maintain health and reduce the morbidity and mortality associated with diseases involving muscle wasting. Recent studies in this field have made tremendous progress; therefore, identification of the mechanisms that regulate skeletal muscle mass is necessary for the physical and nutritional management of both athletes and patients with muscle wasting disease. In this review, we present an overall picture of the interactions regulating skeletal muscle mass, particularly focusing on the insulin-like growth factor-I (IGF-I)/insulin-Akt-mammalian target of rapamycin (mTOR) pathway, skeletal muscle inactivity, and endurance and resistance exercise. We also discuss the contribution of nitric oxide (NO) to the regulation of skeletal muscle mass based on the current knowledge of the novel role of NO in these processes.

Indexed as

fork head box O (FoxO)mammalian target of rapamycin (mTOR)nitric oxide synthase (NOS)reactive oxygen species (ROS)ubiquitin proteasome system (UPS)

Identifiers

PMID32123839
PMCPMC6996321
OpenAlexW2938376661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.