Evidence map›Paper›PMID 32123721›Full record

ArticleMolecular therapy oncolytics2020

MicroRNA Modification of Coxsackievirus B3 Decreases Its Toxicity, while Retaining Oncolytic Potency against Lung Cancer.

Huitao Liu, Yuan Chao Xue, Haoyu Deng, Yasir Mohamud, Chen Seng Ng, Axel Chu, Chinten James Lim, William W Lockwood, William W G Jia, Honglin Luo

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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  15. Signal pathways and precision therapy of small-cell lung cancer.Signal transduction and targeted therapy · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Huitao LiuCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
Yuan Chao XueCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
Haoyu DengCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
Yasir MohamudCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
Chen Seng NgCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
Axel ChuDepartment of Pediatrics, University of British Columbia, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Chinten James LimDepartment of Pediatrics, University of British Columbia, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
William W LockwoodDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
William W G JiaDepartment of Surgery, Division of Neurosurgery, University of British Columbia, Vancouver, BC, Canada.
Honglin LuoCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada.
University of British Columbia · CASt. Paul's Hospital · CABC Children's Hospital · CAOccupational Cancer Research Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently discovered that coxsackievirus B3 (CVB3) is a potent oncolytic virus against

Indexed as

cardiotoxicitycoxsackievirus B3KRAS mutationlung adenocarcinomamiRNA-143miRNA-145oncolytic virussmall-cell lung cancerTP53/RB1 mutationvirotherapy

Identifiers

PMID32123721
PMCPMC7036525
OpenAlexW3002247662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.