Evidence map›Paper›PMID 32123624›Full record

ArticleInternational journal of MCH and AIDS2020

Maternal Caffeine Consumption and Racial Disparities in Fetal Telomere Length.

Isabel Griffin, Boubakari Ibrahimou, Natasha Navejar, Anjali Aggarwal, Kristopher Myers, Daniel Mauck, Korede K Yusuf, Usman J Wudil, Muktar H Aliyu, Hamisu M Salihu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of MCH and AIDS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Isabel GriffinFlorida International University, Robert Stempel College of Public Health and Social Work, Department of Epidemiology, 11200 SW 8 Street #500, Miami, Florida 33174, USA.
Boubakari IbrahimouFlorida International University, Robert Stempel College of Public Health and Social Work, Department of Epidemiology, 11200 SW 8 Street #500, Miami, Florida 33174, USA.
Natasha NavejarCenter of Excellence in Health Equity, Training and Research, Baylor College of Medicine, One Baylor Plaza, MS:411 Houston, TX 77030, USA.
Anjali AggarwalDepartment of Family and Community Medicine, Baylor College of Medicine, 3701 Kirby Drive, Houston, Texas, 77098, USA.
Kristopher MyersFlorida International University, Robert Stempel College of Public Health and Social Work, Department of Epidemiology, 11200 SW 8 Street #500, Miami, Florida 33174, USA.
Daniel MauckFlorida International University, Robert Stempel College of Public Health and Social Work, Department of Epidemiology, 11200 SW 8 Street #500, Miami, Florida 33174, USA.
Korede K YusufAdelphi University, College of Nursing and Public Health, One South Avenue, Garden City, NY 11530, USA.
Usman J WudilVanderbilt University Medical Center, Vanderbilt Institute for Global Health, 2525 West End Ave, Suite 750, Nashville, TN 37203, USA.
Muktar H AliyuVanderbilt University Medical Center, Vanderbilt Institute for Global Health, 2525 West End Ave, Suite 750, Nashville, TN 37203, USA.
Hamisu M SalihuCenter of Excellence in Health Equity, Training and Research, Baylor College of Medicine, One Baylor Plaza, MS:411 Houston, TX 77030, USA.
Florida International University · USBaylor College of Medicine · USVanderbilt University Medical Center · USAdelphi University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe identification of risk factors for shorter telomere length, especially during fetal development, would be important towards caffeine consumption recommendations for pregnant women on a global scale. The purpose of this study was to evaluate the association between caffeine intake and fetal telomere length as well as racial/ethnic differences in telomere length regardless of maternal caffeine consumption status.

methodsCaffeine intake was measured using a food frequency questionnaire (FFQ). Three generalized linear models (GLM) were compared based on binary categorical variables of caffeine levels using data mean value of 117.3 mg as cut-off; the World Health Organization (WHO) recommendations of 300 mg; and the American College of Obstetricians and Gynecologists (ACOG) recommendations of 200 mg. The association between caffeine consumption and telomere length (telomere to single-copy [T/S] ratio) was then assessed.

resultsAmong 57 maternal-fetal dyads, 77.2% reported less than 200 mg of caffeine (ACOG) and 89.5% less than 300 mg (WHO). Both WHO and ACOG models found that caffeine intake was significantly and positively associated with longer telomere length (p<0.05); and sodium (p<0.05). Other" race (p<0.001) and "white" race (p<0.001) were also significantly and positively associated with longer telomere length in the same models. Increasing maternal age shortened telomere length significantly in all models (p<0.001). CONCLUSION AND GLOBAL HEALTH IMPLICATIONS: Caffeine intake, maternal age, and race may be associated with alterations in fetal telomere length. This indicates that caffeine consumption during pregnancy may have long-term implications for fetal development. The racial/ethnic differences in telomere length found in this study warrant larger studies to further confirm these associations.

Indexed as

CaffeineFetal telomere lengthMaternal-Fetal medicinePregnancyRacial/ethnic differencesTelomere

Identifiers

PMID32123624
PMCPMC7031881
OpenAlexW3013138116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.