ArticleNature methods2020
A virtual reality system to analyze neural activity and behavior in adult zebrafish.
Article in Nature methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Closed-loop real-virtual interactions validate 3D model of social coordination in fish.PLoS computational biology · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- MARINER: a surround visual stimulator for vision research in aquatic animals.bioRxiv : the preprint server for biology · 2026Article
- Virtual social interaction reveals that the dorsal habenula-IPN pathway is essential for targeting the opponent.iScience · 2026Article
- Unsupervised transfer learning enables multi-animal tracking without training annotation.Nature methods · 2026Article
- Distinct distributed neural dynamics predict pallium-dependent social approach.Nature communications · 2026Article
- An open-source closed-loop Virtual Reality system to investigate social interactions and collective behavior in fish.PloS one · 2026Article
- Microfluidics-Enabled Simultaneous Imaging of Neural Activity and Behavior in Chemically Stimulated, Head-FixedbioRxiv : the preprint server for biology · 2025Article
- The lab-field continuum in conservation physiology research: leveraging multiple approaches to inform policy and practice.Conservation physiology · 2025Article
- Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system.Cell reports methods · 2024Article
- Understanding collective behavior through neurobiology.Current opinion in neurobiology · 2024Review
- Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon.Current biology : CB · 2024Article
- Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights.Frontiers in molecular neuroscience · 2024Review
- Advancements in brain-machine interfaces for application in the metaverse.Frontiers in neuroscience · 2024Review
- The application of metaverse in healthcare.Frontiers in public health · 2024Review
- An automated, low-latency environment for studying the neural basis of behavior in freely moving rats.BMC biology · 2023Article
- Convergent Energy State-Dependent Antagonistic Signaling by Cocaine- and Amphetamine-Regulated Transcript (CART) and Neuropeptide Y (NPY) Modulates the Plasticity of Forebrain Neurons to Regulate Feeding in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish.Nature communications · 2023Article
- Extended reality for biomedicine.Nature reviews. Methods primers · 2023Article
- Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy.iScience · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Virtual realities are powerful tools to analyze and manipulate interactions between animals and their environment and to enable measurements of neuronal activity during behavior. In many species, however, optical access to the brain and/or the behavioral repertoire are limited. We developed a high-resolution virtual reality for head-restrained adult zebrafish, which exhibit cognitive behaviors not shown by larvae. We noninvasively measured activity throughout the dorsal telencephalon by multiphoton calcium imaging. Fish in the virtual reality showed regular swimming patterns and were attracted to animations of conspecifics. Manipulations of visuo-motor feedback revealed neurons that responded selectively to the mismatch between the expected and the actual visual consequences of motor output. Such error signals were prominent in multiple telencephalic areas, consistent with models of predictive processing. A virtual reality system for adult zebrafish therefore provides opportunities to analyze neuronal processing mechanisms underlying higher brain functions including decision making, associative learning, and social interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.