ArticleNature neuroscience2020
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD.
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Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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121citing papers in PubMed
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Who cites it
121 citing papers in PubMed, 195 citations in OpenAlex.
- Differential GABA dynamics across brain functional networks in autism.Communications biology · 2026Trial
- Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder.Translational psychiatry · 2023Trial
- Hunger recruits a parallel circuit encoding alcohol reward.Current biology : CB · 2026Article
- Effects of early-life tactile experience enrichment on autistic-like behaviors and synaptic alterations inFundamental research · 2026Article
- Rapid neuronal labeling and functional imaging in the developing mouse brain with AAV-PHP.eB.Cell reports methods · 2026Article
- Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in abioRxiv : the preprint server for biology · 2026Article
- Diverse excess GABA modes drive autism and epilepsy-autism comorbidity.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- A modified FLIT-B model of trigeminal neuralgia reveals anterior cingulate cortex involvement in anxiety-like behavior in mice.The journal of headache and pain · 2026Article
- Article
- Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.Nature neuroscience · 2026Article
- Disrupted Development of the mPFC-Thalamic Circuit in Shank3Molecular psychiatry · 2026Article
- Diminished Signal-to-Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Beta power as a neural correlate of sensory features in autistic individuals.Journal of neurodevelopmental disorders · 2026Article
- Shank3B deficiency disrupts GABAergic synaptic transmission in pyramidal neurons of the medial prefrontal cortex region in autism spectrum disorder.Molecular brain · 2026Article
- Applications and potential mechanisms of transcranial magnetic stimulation in autism spectrum disorders.Journal of translational medicine · 2026Review
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
- Stem Cell Therapy and Models for Autism Spectrum Disorder: Insights and Research.Current neuropharmacology · 2026Review
- Rubber tail illusion is not obvious in SH3 and multiple ankyrin repeat domains 3 (Oxford open neuroscience · 2026Article
- USP19 restores mitochondrial function in neurons by deubiquitinating FUS to alleviate trigeminal neuralgia.Experimental brain research · 2025Article
- Degraded sensory coding in a mouse model ofbioRxiv : the preprint server for biology · 2025Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors at 6 institutions in 2 countries.
Qian Chen *McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Christopher A Deister *Department of Neuroscience, Brown University, Providence, RI, USA.
Xian GaoMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Baolin GuoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Taylor Lynn-JonesMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Naiyan ChenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Michael F WellsStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Runpeng LiuMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Michael J GoardDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-5366-8501
Jordane DimidschsteinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6289-6891
Shijing FengGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yiwu ShiInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.ORCID http://orcid.org/0000-0002-7962-8874
Weiping LiaoInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Zhonghua LuGuangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Gord FishellStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Christopher I MooreDepartment of Neuroscience, Brown University, Providence, RI, USA. Christopher_moore@brown.edu.ORCID http://orcid.org/0000-0003-4534-1602
Guoping FengMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. fengg@mit.edu.ORCID http://orcid.org/0000-0002-8021-277X
Broad Institute · USMcGovern Institute for Brain Research · USBrown University · USChinese Academy of Sciences · CNSecond Affiliated Hospital of Guangzhou Medical University · CNUniversity of California, Santa Barbara · US
Funding
Res Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI LICHTMAN, JEFF W · 2011 to 2022
$18.6MSystematic in vivo Testing of the Fast-Spiking Synchrony HypothesisR01NS045130 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MOORE, CHRISTOPHER I · 2003 to 2017
$3.5MShank3 in Synaptic Function and AutismR01MH097104 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING · 2012 to 2016
$2.0MDissection of the neural circuitry of short-term memory in behaving miceR00MH104259 · NIMH · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GOARD, MICHAEL · 2016 to 2018
$747kSystematic Testing of a Neocortical Gamma Gain HypothesisF32MH100749 · NIMH · BROWN UNIVERSITY · PI DEISTER, CHRISTOPHER ALLEN · 2013 to 2015
$165kNIMH NIH HHS F32 MH100749NIMH NIH HHS P50 MH094271NIMH NIH HHS R00 MH104259NIMH NIH HHS R01 MH097104NINDS NIH HHS R01 NS045130
Abstract
Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not completely understood. Here we examined the neural representations of sensory perception in the neocortex of a Shank3B
Indexed as
Action PotentialsAnimalsAutism Spectrum DisorderDisease Models, AnimalGABAergic NeuronsMiceMicrofilament ProteinsNerve Tissue ProteinsPhysical StimulationPyramidal CellsSensory ThresholdsSomatosensory CortexTouchTouch PerceptionMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.