ArticleEuropean journal of clinical nutrition2020
Phase angle is not associated with fatigue in cancer patients: the hydration impact.
Article in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Phase Angle and Extracellular Water-to-Total Body Water Ratio Measured by Bioelectrical Impedance Analysis Are Associated with Anemia and Hemoglobin Levels in Women with Type 2 Diabetes: A Cross-Sectional Study.Health science reports · 2026Article
- Perioperative phase angle decline is associated with postoperative sarcopenia in esophageal cancer: a longitudinal cohort study with internal validation.Frontiers in nutrition · 2026Article
- Positive association of the thigh muscle thickness to intracellular-water ratio with handgrip strength, but not with the risk of mortality in hospitalized cancer patients: a longitudinal study.European journal of clinical nutrition · 2025Review
- Article
- Hemoglobin and hematocrit levels are positively correlated with phase angle in mixed cancer patients: an exploratory cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Impact assessment of integrated-pathy on cancer-related fatigue in cancer patients: an observational study.Journal of health, population, and nutrition · 2024Observational
- Association between Phase Angle and Subjective Perceptions of Health Variables in Cancer Patients.Healthcare (Basel, Switzerland) · 2023Article
- Diagnostic and prognostic utility of phase angle in patients with cancer.Reviews in endocrine & metabolic disorders · 2023Review
- Article
- Body Composition and COPD: A New Perspective.International journal of chronic obstructive pulmonary disease · 2023Review
- Bioelectrical phase angle is no adequate biomarker of inflammatory status.International journal of obesity (2005) · 2022Article
- Phase Angle, a Cornerstone of Outcome in Head and Neck Cancer.Nutrients · 2022Article
- Absence of risk of sarcopenia protects cancer patients from fatigue.European journal of clinical nutrition · 2022Article
- Fatigue Is Not Associated with Phase Angle in Hemodialysis Patients.The journal of nutrition, health & aging · 2022Article
- High neutrophil to lymphocytes ratio is associated with nutritional risk in hospitalised, unselected cancer patients: a cross-sectional study.Scientific reports · 2021Article
- Correlation between the SARC-F Score and Hydration Status in Older Gastrointestinal Cancer Outpatients.The journal of nutrition, health & aging · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer patients suffer from metabolic and pathophysiological changes that contribute to malnutrition. These metabolic changes lead to loss of cell integrity, which induces dehydration intracellular and increase extracellular fluid. Bioelectrical impedance analysis (BIA)-derived phase angle (PhA) is considered a good tool to evaluate hydration status, but in cancer patients it is not fully elucidated. Thus, in cancer patients the aims of this study were to (1) verify the association between PhA and fatigue, (2) verify the association between PhA and fatigue after adjustment for extracellular fluid accumulation, and (3) assess the prevalence of fatigue. This cross-sectional study was conducted with 124 patients of both genders on cancer treatment. Body weight, height, body mass index, handgrip strength, performance status, and cachexia were collected. In addition, body composition was evaluated by BIA to obtain hydration status and PA. The cut-off point used to classify patients with low PhA was set <4°. To identify fatigue, the Functional Assessment of Cancer Therapy Fatigue questionnaire was applied. Of the 124 patients evaluated (n = 98/79% men), 26% had fatigue. The prevalence of fatigue was higher in patients with lower PhA <4° (65.63%). In the logistic regression analyses, we found that patients with PhA >4° had lower risk for fatigue (OR: 0.92 95% CI [0.86-0.99], p = 0.03) in the crude model, however after adjustments by weight loss percentage in 6 months, age, sex, and hydration the association was not maintained (OR: 0.94 95% CI [0.85-1.04], p = 0.26). In conclusion, we found that ~26% of cancer patients have fatigue. In spite of adjustment for extracellular fluid, PhA is not associated with fatigue. The importance of measuring PhA to assess intra and extracellular hydration in cancer patients is highlighted.
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