Evidence map›Paper›PMID 32123231›Full record

ArticleScientific reports2020

PET imaging of medulloblastoma with an

Yangchun Xin, Xuyi Yue, Hua Li, Zhiqin Li, Hancheng Cai, Arabinda K Choudhary, Shaohui Zhang, Diane C Chugani, Sigrid A Langhans

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Improved automated one-pot two-step radiosynthesis of (S)-[EJNMMI radiopharmacy and chemistry · 2024
    Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yangchun Xin *Katzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.ORCID http://orcid.org/0000-0002-2270-133X
Xuyi Yue *Katzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
Hua LiKatzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
Zhiqin LiNemours Center for Childhood Cancer Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
Hancheng CaiMayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Arabinda K ChoudharyDepartment of Radiology, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
Shaohui ZhangKatzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
Diane C ChuganiKatzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA.
Sigrid A LanghansNemours Center for Childhood Cancer Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, 19803, USA. Sigrid.Langhans@nemours.org.
Alfred I. duPont Hospital for Children · USMayo Clinic in Florida · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Center for Pediatric ResearchP20GM103464 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2012 to 2014
$5.6M
Center for Pediatric Research Pilot ProgramP30GM114736 · NIGMS · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI SHAFFER, THOMAS H · 2015 to 2019
$5.1M
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P20-GM103464U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P30-GM114736U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) U54-GM104941
6 · The paper itself

Abstract

In vivo positron emission tomography (PET) imaging is a key modality to evaluate disease status of brain tumors. In recent years, tremendous efforts have been made in developing PET imaging methods for pediatric brain tumors. Carbon-11 labelled tryptophan derivatives are feasible as PET imaging probes in brain tumor patients with activation of the kynurenine pathway, but the short half-life of carbon-11 limits its application. Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here we evaluated the potential of the newly developed 1-(2-[

Indexed as

AnimalsBiological TransportBrain NeoplasmsFluorine RadioisotopesHumansMedulloblastomaMiceMice, TransgenicPositron-Emission TomographyRadiopharmaceuticalsTryptophanFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsTryptophan

Identifiers

PMID32123231
PMCPMC7051973
OpenAlexW3010630372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.