ArticleProceedings of the National Academy of Sciences of the United States of America2020
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
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Who cites it
59 citing papers in PubMed, 103 citations in OpenAlex.
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- H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases.Frontiers in immunology · 2025Article
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Corrections and comments
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Authors and funding
17 authors at 8 institutions in 5 countries.
Adam P CribbsBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom; adam.cribbs@imm.ox.ac.uk marc.feldmann@kennedy.ox.ac.uk udo.oppermann@sgc.ox.ac.uk.ORCID 0000-0001-5288-3077
Stefan Terlecki-ZaniewiczBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom.
Martin PhilpottBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom.
Jeroen BaardmanExperimental Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, University of Amsterdam, 1105AZ Amsterdam, The Netherlands.
David AhernKennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7FY Oxford, United Kingdom.
Morten LindowRoche Innovation Center Copenhagen A/S, DK 2970 Hørsholm, Denmark.
Susanna ObadRoche Innovation Center Copenhagen A/S, DK 2970 Hørsholm, Denmark.
Henrik OerumRoche Innovation Center Copenhagen A/S, DK 2970 Hørsholm, Denmark.
Brante SampeyMetabolon Inc., Durham, NC 27713.
Palwinder K ManderEpinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D, SG1 2NY Stevenage, United Kingdom.
Henry PennArthritis Centre, Northwick Park Hospital, HA13UJ Harrow, United Kingdom.
Paul WordsworthBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom.
Paul BownessBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom.
Menno de WintherInstitute for Cardiovascular Prevention, Ludwig Maximilians University, 80336 Munich, Germany.
Rab K PrinjhaEpinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D, SG1 2NY Stevenage, United Kingdom.ORCID 0000-0002-2666-3326
Marc FeldmannBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom; adam.cribbs@imm.ox.ac.uk marc.feldmann@kennedy.ox.ac.uk udo.oppermann@sgc.ox.ac.uk.ORCID 0000-0003-0800-7840
Udo OppermannBotnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom; adam.cribbs@imm.ox.ac.uk marc.feldmann@kennedy.ox.ac.uk udo.oppermann@sgc.ox.ac.uk.
National Institute for Health Research · GBRoche (Denmark) · DKGlaxoSmithKline (United Kingdom) · GBAmsterdam University Medical Centers · NLLudwig-Maximilians-Universität München · DEMetabolon (United States) · USNorthwick Park Hospital · GBUniversity of Freiburg · DE
Funding
Arthritis Research UK 20522Cancer Research UK CRUKDF-0318-AC[AZ]CIHRDepartment of HealthMedical Research Council G1000902Versus Arthritis 20402Versus Arthritis 20522Wellcome Trust
Abstract
T helper (Th) cells are CD4
Indexed as
Autoimmune DiseasesBenzazepinesCell DifferentiationCells, CulturedDown-RegulationHistone CodeHistone DemethylasesHistonesHumansInterleukin-17Jumonji Domain-Containing Histone DemethylasesPrimary Cell CulturePyrimidinesRNA-SeqSpondylitis, AnkylosingTh17 CellsBenzazepinesGSK-J4Histone DemethylasesHistonesInterleukin-17Jumonji Domain-Containing Histone DemethylasesKDM6A protein, humanKDM6B protein, humanperoxisome-proliferator-activated receptor-gamma coactivator-1PyrimidinesTranscription Factorsepigeneticshistone demethylaseinflammationmetabolismTh17 cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.