Evidence map›Paper›PMID 32123095›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.

Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Hebatullah Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Wittig, Eiman Elwakeel, Bernhard Brüne and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rushendhiran KesavanInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.
Timo FrömelInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.
Sven ZukunftInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.ORCID 0000-0002-1811-4562
Hebatullah LabanInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.
Alexandra GeyerInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.
Zumer NaeemInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.
Juliana HeidlerGerman Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60590 Frankfurt, Germany.
Ilka WittigGerman Centre for Cardiovascular Research (DZHK), Partner Site RheinMain, 60590 Frankfurt, Germany.
Eiman ElwakeelInstitute of Biochemistry I, Goethe-University, 60590 Frankfurt am Main, Germany.
Bernhard BrüneInstitute of Biochemistry I, Goethe-University, 60590 Frankfurt am Main, Germany.
Andreas WeigertInstitute of Biochemistry I, Goethe-University, 60590 Frankfurt am Main, Germany.
Rüdiger PoppInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany.
Ingrid FlemingInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, 60590 Frankfurt am Main, Germany; fleming@em.uni-frankfurt.de.ORCID 0000-0003-1881-3635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor growth and metastasis, largely on the basis of overexpression studies and the application of exogenous epoxides. Here we studied tumor growth and metastasis in Cyp2c44

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBreast NeoplasmsCytochrome P450 Family 2Disease Models, AnimalEndothelial CellsFatty Acids, UnsaturatedLung NeoplasmsLymphangiogenesisMacrophagesMiceMice, KnockoutMonocytesNeoplastic ProcessesProstaglandinsProteomics12-hydroxy-5,8,10-heptadecatrienoic acidAdaptor Proteins, Signal TransducingCyp2c23 protein, mouseCytochrome P450 Family 2Fatty Acids, UnsaturatedProstaglandinsToll-Like ReceptorsWdfy1 protein, mousecytochrome P450lymphangiogenesismetastasisWDFY1

Identifiers

PMID32123095
PMCPMC7084120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.