Evidence map›Paper›PMID 32123086›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

CUL3

Jose Manuel Chico, Esther Lechner, Gemma Fernandez-Barbero, Esther Canibano, Gloria García-Casado, Jose Manuel Franco-Zorrilla, Philippe Hammann, Angel M Zamarreño, Jose M García-Mina, Vicente Rubio and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 115 citations in OpenAlex.

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  20. Bioinformatic Analysis of the BTB Gene Family inPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jose Manuel ChicoDepartamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
Esther LechnerInstitut de Biologie Moléculaire des Plantes, CNRS, Université de Strasbourg, 67084 Strasbourg, France.
Gemma Fernandez-BarberoDepartamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
Esther CanibanoDepartamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
Gloria García-CasadoGenomics Unit, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
Jose Manuel Franco-ZorrillaGenomics Unit, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.ORCID 0000-0001-6769-7349
Philippe HammannInstitut de Biologie Moléculaire et Cellulaire, CNRS FR1589, Plateforme Protéomique Strasbourg-Esplanade, Université de Strasbourg, 67084 Strasbourg, France.
Angel M ZamarreñoDepartment of Environmental Biology, University of Navarra, 31008 Navarra, Spain.
Jose M García-MinaDepartment of Environmental Biology, University of Navarra, 31008 Navarra, Spain.
Vicente RubioDepartamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.ORCID 0000-0002-8800-2400
Pascal GenschikInstitut de Biologie Moléculaire des Plantes, CNRS, Université de Strasbourg, 67084 Strasbourg, France.ORCID 0000-0002-4107-5071
Roberto SolanoDepartamento de Genética Molecular de Plantas, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain; rsolano@cnb.csic.es.ORCID 0000-0001-5459-2417
Consejo Superior de Investigaciones Científicas · ESCentre National de la Recherche Scientifique · FRUniversidad de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The jasmonate (JA)-pathway regulators MYC2, MYC3, and MYC4 are central nodes in plant signaling networks integrating environmental and developmental signals to fine-tune JA defenses and plant growth. Continuous activation of MYC activity is potentially lethal. Hence, MYCs need to be tightly regulated in order to optimize plant fitness. Among the increasing number of mechanisms regulating MYC activity, protein stability is arising as a major player. However, how the levels of MYC proteins are modulated is still poorly understood. Here, we report that MYC2, MYC3, and MYC4 are targets of BPM (BTB/POZ-MATH) proteins, which act as substrate adaptors of CUL3-based E3 ubiquitin ligases. Reduction of function of CUL3

Indexed as

ArabidopsisArabidopsis ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCullin ProteinsCyclopentanesFeedback, PhysiologicalGene Expression Regulation, PlantMutationOxylipinsPlant RootsPlants, Genetically ModifiedProtein StabilityProteolysisRecombinant ProteinsTrans-ActivatorsUbiquitinationArabidopsis ProteinsAT1G26830 protein, ArabidopsisBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCullin ProteinsCyclopentanesjasmonic acidMYC2 protein, ArabidopsisMYC3 protein, ArabidopsisMYC4 protein, ArabidopsisOxylipinsRecombinant ProteinsTrans-ActivatorsCullin ring ligasesjasmonate signalingMYC2phytohormoneproteasome

Identifiers

PMID32123086
PMCPMC7084108
OpenAlexW3009810519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.