Evidence map›Paper›PMID 32123044›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2020

Cortical topological network changes following optic neuritis.

Yael Backner, Ido Ben-Shalom, Joseph Kuchling, Nadja Siebert, Michael Scheel, Klemens Ruprecht, Alexander Brandt, Friedemann Paul, Netta Levin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Clinical and neuroimaging findings in MOGAD-MRI and OCT.Clinical and experimental immunology · 2021
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Yael BacknerFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.
Ido Ben-ShalomFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.
Joseph KuchlingFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.
Nadja SiebertFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.
Michael ScheelFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.ORCID 0000-0002-3505-2914
Klemens RuprechtFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.
Alexander BrandtFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.ORCID 0000-0002-9768-014X
Friedemann PaulFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine.
Netta LevinFrom the fMRI Unit (Y.B., I.B.-S., N.L.), Neurology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Experimental and Clinical Research Center (J.K., N.S., A.B., F.P.), Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Germany; NeuroCure Clinical Research Center (J.K., N.S., M.S., A.B., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology (J.K., K.R., F.P.), Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany; Department of Neuroradiology (M.S.), Charité-Universitätsmedizin Berlin, Germany; and Department of Neurology (A.B.), University of California, Irvine. netta@hadassah.org.il.
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo differentiate between visual cortical network topology changes following optic neuritis (ON) stemming from different inflammatory disease types, we used mathematical graph theory-based tools to analyze functional imaging data.

methodsSixty-two patients were recruited into this cross-sectional study, 23 of whom had neuromyelitis optica spectrum disorder (NMOSD) with ON, 18 with clinically isolated syndrome (CIS)-ON, and 21 with other CIS episodes. Twenty-six healthy controls (HCs) were also recruited. All participants underwent resting-state functional MRI. Visual networks were defined using 50 visual regions of interest. Analysis included graph theory metrics, including degree, density, modularity, and local and global efficiency.

resultsVisual network density shows decreased connectivity in all patient groups compared with controls. A higher degree of connections is seen in both ON groups (CIS and NMOSD) compared with the the non-ON group. This pattern is most pronounced in dorsal-lateral regions. Information transfer efficiency and modularity were reduced in both CIS groups, but not in the NMOSD group, compared with the HC group.

conclusionsVisual network density appears affected by the neurologic deficit sustained (ON), and connectivity changes are more evident in dorsal-lateral regions. Efficiency and modularity appear to be associated with the specific disease type (CIS vs NMOSD). Thus, topological cortical changes in the visual system are associated with the type of neurologic deficit within the limits set on them by the underlying pathophysiology. We suggest that cortical patterns of activity should be considered in the outcome of the patients despite the localized nature of ON.

Indexed as

Brain MappingCerebral CortexNerve NetOptic NeuritisAdultConnectomeCross-Sectional StudiesEcho-Planar ImagingFemaleHumansMaleMiddle Aged

Identifiers

PMID32123044
PMCPMC7136064
OpenAlexW3009813862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.