Evidence map›Paper›PMID 32123037›Full record

ArticleJournal of bacteriology2020

Ribosome Dimerization Protects the Small Subunit.

Heather A Feaga, Mykhailo Kopylov, Jenny Kim Kim, Marko Jovanovic, Jonathan Dworkin

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Structural insights into RNA recognition by theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Suppressor analysis inFrontiers in microbiology · 2026
    Article
  9. Article
  10. Article
  11. A link between aging and persistence.Antimicrobial agents and chemotherapy · 2025
    Article
  12. Article
  13. Hibernating ribosomes as drug targets?Frontiers in microbiology · 2024
    Review
  14. Review
  15. Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Heather A FeagaDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Mykhailo KopylovSimons Electron Microscopy Center, New York Structural Biology Center, New York, New York, USA.
Jenny Kim KimDepartment of Biological Sciences, Columbia University, New York, New York, USA.
Marko JovanovicDepartment of Biological Sciences, Columbia University, New York, New York, USA.
Jonathan DworkinDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, New York, USA jonathan.dworkin@columbia.edu.ORCID 0000-0002-8205-6918
Columbia University · USNew York Structural Biology Center · US

Funding

ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Regulation of Protein Production Dynamics:RNA Binding Proteins and the Ribosome CodeR35GM128802 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI JOVANOVIC, MARKO · 2018 to 2022
$2.3M
Regulation of Protein Synthesis in Bacteria by Ser/Thr PhosphorylationR01GM114213 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DWORKIN, JONATHAN · 2015 to 2018
$1.4M
Physiological responses to cell wall-active antibiotics in a Gram-positive bacteriumR21AI135427 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DWORKIN, JONATHAN · 2018 to 2019
$440k
Reversible regulation of ribosome recycling by Ser/Thr phosphorylationF32GM122266 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FEAGA, HEATHER · 2017 to 2019
$177k
NCRR NIH HHS P41 RR001209NIAID NIH HHS R21 AI135427NIGMS NIH HHS F32 GM122266NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM114213NIGMS NIH HHS R35 GM128802Wellcome Trust
6 · The paper itself

Abstract

When nutrients become scarce, bacteria can enter an extended state of quiescence. A major challenge of this state is how to preserve ribosomes for the return to favorable conditions. Here, we show that the ribosome dimerization protein hibernation-promoting factor (HPF) functions to protect essential ribosomal proteins. Ribosomes isolated from strains lacking HPF (Δ

Indexed as

Bacillus subtilisBacterial ProteinsCryoelectron MicroscopyDimerizationRibosomesRibosome Subunits, SmallBacterial Proteinsstationary phasetranslation

Identifiers

PMID32123037
PMCPMC7186458
OpenAlexW3007800139

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.