Evidence map›Paper›PMID 32122952›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes.

Joanne Falck, Christine Bruns, Sheila Hoffmann-Conaway, Isabelle Straub, Erik J Plautz, Marta Orlando, Humaira Munawar, Marion Rivalan, York Winter, Zsuzsanna Izsvák and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Pontocerebellar Hypoplasia Type 3 With Two NovelCase reports in pediatrics · 2025
    Article
  4. Presynaptic Cytomatrix Proteins.Advances in neurobiology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Joanne FalckGerman Center for Neurodegenerative Diseases, Charité Medical University, 10117 Berlin, Germany.
Christine BrunsGerman Center for Neurodegenerative Diseases, Charité Medical University, 10117 Berlin, Germany.
Sheila Hoffmann-ConawayGerman Center for Neurodegenerative Diseases, Charité Medical University, 10117 Berlin, Germany.
Isabelle StraubCarl-Ludwig Institute for Physiology, 04103 Leipzig, Germany.
Erik J PlautzDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern, Dallas, Texas 75390.
Marta OrlandoCharité Medical University Berlin and Berlin Institute of Health, NeuroCure Cluster of Excellence, 10117 Berlin, Germany.
Humaira MunawarDepartment of Biology, Humboldt University, 10099 Berlin, Germany.
Marion RivalanCharité Medical University Berlin and Berlin Institute of Health, NeuroCure Cluster of Excellence, 10117 Berlin, Germany.
York WinterCharité Medical University Berlin and Berlin Institute of Health, NeuroCure Cluster of Excellence, 10117 Berlin, Germany.
Zsuzsanna IzsvákMax Delbrück Center for Molecular Medicine in the Helmholtz Society, 13125 Berlin, Germany, and.
Dietmar SchmitzCharité Medical University Berlin and Berlin Institute of Health, NeuroCure Cluster of Excellence, 10117 Berlin, Germany.
F Kent HamraDepartment of Obstetrics and Gynecology, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern, Dallas, Texas 75390.
Stefan HallermannCarl-Ludwig Institute for Physiology, 04103 Leipzig, Germany.
Craig Curtis GarnerGerman Center for Neurodegenerative Diseases, Charité Medical University, 10117 Berlin, Germany.
Frauke AckermannGerman Center for Neurodegenerative Diseases, Charité Medical University, 10117 Berlin, Germany, Frauke.Ackermann@dzne.de.ORCID 0000-0003-3037-8672
German Center for Neurodegenerative Diseases · DEHumboldt-Universität zu Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DELudwig Cancer Research · BEThe University of Texas Southwestern Medical Center · USMax Delbrück Center · DE

Funding

Sperm Stem Cell Libraries for Biological ResearchR24OD011108 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI HAMRA, F. KENT · 2012 to 2014
$1.7M
NIH HHS R24 OD011108
6 · The paper itself

Abstract

Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypoplasia type 3 (PCH3). We have characterized recently generated Piccolo KO (

Indexed as

Olivopontocerebellar AtrophiesAnimalsCerebellumCytoskeletal ProteinsDisease Models, AnimalFemaleGene Knockout TechniquesMaleNeuropeptidesPhenotypeRatsCytoskeletal ProteinsNeuropeptidesPclo protein, ratactive zonePiccolopontocerebellar hypoplasiapresynapse

Identifiers

PMID32122952
PMCPMC7117892
OpenAlexW3010212032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.