ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020
Non-invasive imaging of single human motor units.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 38 citations in OpenAlex.
- Identification of single motor units in skeletal muscle under low force isometric voluntary contractions using ultrafast ultrasound.Scientific reports · 2020Trial
- Skeletal Motor Unit Recruitment During Periodic Auditory Cueing: A Simultaneous Behavioral and Motor Unit Magnetic Resonance Imaging (MUMRI) Study.NMR in biomedicine · 2026Article
- MRI of Neurogenic Human Motor Units Following Poliomyelitis.Muscle & nerve · 2026Article
- The dynamic course of spontaneous muscular contractions assessed using multiple-point acquisition in diffusion-weighted stimulated echo imaging.Magnetic resonance in medicine · 2026Article
- Measurement of Twitch Dynamics in Response to Exercise Induced Changes in Mitochondrial Disease Using Motor Unit Magnetic Resonance Imaging (MUMRI): A Proof-of-Concept Study.NMR in biomedicine · 2025Article
- Ultrasound-guided motor unit scanning electromyography.Muscle & nerve · 2022Article
- Modelling intra-muscular contraction dynamics using in silico to in vivo domain translation.Biomedical engineering online · 2022Article
- Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin.Biomolecules · 2021Article
- The muscle twitch profile assessed with motor unit magnetic resonance imaging.NMR in biomedicine · 2021Article
- The role of novel motor unit magnetic resonance imaging to investigate motor unit activity in ageing skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2021Review
- Comparison of Shifts in Skeletal Muscle Plasticity Parameters in Horses in Three Different Muscles, in Answer to 8 Weeks of Harness Training.Frontiers in veterinary science · 2021Article
- Diffusion Tensor Imaging of Skeletal Muscle Contraction Using Oscillating Gradient Spin Echo.Frontiers in neurology · 2021Article
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5 authors at 2 institutions in 1 country.
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Abstract
objectiveTo determine the size, shape and distribution of single human motor units in-vivo in healthy controls of different ages.
methodsA novel diffusion-weighted magnetic resonance imaging (MRI) technique was used in combination with in-scanner electrical stimulation to quantify the shape, cross-sectional area, and dimensions of individual motor units in 10 healthy subjects.
resultsThirty-one discrete motor units were studied. The majority were elliptical or crescent shaped, but occasional split motor units were observed. The mean motor unit cross sectional area was 26.7 ± 11.2 mm
conclusionsMotor unit MRI (MUMRI) is a novel technique capable of revealing the size, shape and position of multiple motor units in human muscles. It is reproducible, non-invasive, and sufficiently sensitive to detect physiologically relevant changes in motor unit morphology with age. SIGNIFICANCE: To our knowledge, these results provide the first imaging assessment of human motor unit morphology. The technique shows promise both as a diagnostic tool and as a biomarker in longitudinal studies of disease progression.
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