ArticleBMC medicine2020
Functional somatic disorders: discussion paper for a new common classification for research and clinical use.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06232473 (Efficacy of Patient Education and Duloxetine, Alone or in Combination, for Patients With Multisystem Functional Somatic Disorder), which is not on this map. Cited by 116 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Patient Education and Duloxetine, Alone or in Combination, for Patients With Multisystem Functional Somatic Disorder
Who cites it
116 citing papers in PubMed, 9 syntheses or guidelines pooled it, 275 citations in OpenAlex.
- Understanding General Somatic Symptom Burden: Insights from a Systematic Review of Factor Analyses Pertaining to the Patient Health Questionnaire 15 (PHQ-15) and Somatic Symptom Scale 8 (SSS-8).International journal of behavioral medicine · 2026Pooled it
- Factors associated with receiving a Functional Disorder diagnostic label: A systematic review.PloS one · 2025Pooled it
- Prevalence of functional disorders across Europe: a systematic review and meta-analysis.European journal of epidemiology · 2024Pooled it
- Clinical skills development for healthcare practitioners working with patients with persistent physical symptoms (PPS) in healthcare settings: a systematic review and narrative synthesis.BMC medical education · 2024Pooled it
- What psychological interventions are effective for the management of persistent physical symptoms (PPS)? A systematic review and meta-analysis.British journal of health psychology · 2023Pooled it
- Pooled it
- Early Psychological Interventions for Somatic Symptom Disorder and Functional Somatic Syndromes: A Systematic Review and Meta-Analysis.Psychosomatic medicine · 2022Pooled it
- Epidemiology and organisation of care in medically unexplained symptoms: A systematic review with a focus on cultural diversity and migrants.International journal of clinical practice · 2021Pooled it
- Predictors of Treatment Success of Psychotherapy in Functional Disorders: A Systematic Review of the Literature.Clinical psychology & psychotherapyPooled it
- Effect of internet-delivered exposure therapy versus healthy lifestyle promotion for patients with persistent physical symptoms (SOMEX1): a randomized controlled trial with planned moderator analysis.Psychological medicine · 2025Trial
- Large Language Models as a New Tool for Therapists in Internet-Based Cognitive Behavioral Therapy: Blinded Clinician Rating Pilot Experiment.JMIR mental health · 2026Article
- Psychosomatic Burden and Childhood Trauma in Chronic Pruritus without Primary Dermatosis or Systemic Disease: A Case-control Study.Acta dermato-venereologica · 2026Article
- Insulin, Glucose and Lipid Biomarkers as Possible Risk Factors for Functional Somatic Disorder: A Five-Year Follow-Up of the DanFunD Cohort.Journal of clinical medicine · 2026Article
- Are Conditioned Pain Modulation and Pain Sensitivity Risk Factors for the Development of Functional Somatic Disorder? A Longitudinal Population-Based Study.European journal of pain (London, England) · 2026Article
- An alternative "Port"? Rationale and development process for POts Reprocessing Therapy (PORT), a brain-body therapy for postural tachycardic syndrome (POTS).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Patient experiences with internet-based cognitive behavioral therapy for multi-system functional somatic disorder: A qualitative study.Internet interventions · 2026Article
- Guided versus unguided internet-administered emotional awareness and expression therapy (I-EAET) for patients with persistent physical symptoms: A randomized trial.Internet interventions · 2026Article
- Untangling the Osteopathic Gordian Knot: Reconceptualized Principles for Sustainable and Contemporary Clinical Practice-A Conceptual Perspective.Healthcare (Basel, Switzerland) · 2026Article
- Who benefits from multidisciplinary care in functional somatic disorders? Identifying cost-effective patient selection through diagnostic classification groups.Israel journal of health policy research · 2026Article
- Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundFunctional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients' quality of life and healthcare costs. MAIN BODY: We outline five problems pointing to the need for a new classification: (1) developments in understanding aetiological mechanisms; (2) the current division of disorders according to the treating specialist; (3) failure of current classifications to cover the variety of disorders and their severity (for example, patients with symptoms from multiple organs systems); (4) the need to find acceptable categories and labels for patients that promote therapeutic partnership; and (5) the need to develop clinical services and research for people with severe disorders. We propose 'functional somatic disorders' (FSD) as an umbrella term for various conditions characterised by persistent and troublesome physical symptoms. FSDs are diagnosed clinically, on the basis of characteristic symptom patterns. As with all diagnoses, a diagnosis of FSD should be made after considering other possible somatic and mental differential diagnoses. We propose that FSD should occupy a neutral space within disease classifications, favouring neither somatic disease aetiology, nor mental disorder. FSD should be subclassified as (a) multisystem, (b) single system, or (c) single symptom. While additional specifiers may be added to take account of psychological features or co-occurring diseases, neither of these is sufficient or necessary to make the diagnosis. We recommend that FSD criteria are written so as to harmonise with existing syndrome diagnoses. Where currently defined syndromes fall within the FSD spectrum - and also within organ system-specific chapters of a classification - they should be afforded dual parentage (for example, irritable bowel syndrome can belong to both gastrointestinal disorders and FSD).
conclusionWe propose a new classification, 'functional somatic disorder', which is neither purely somatic nor purely mental, but occupies a neutral space between these two historical poles. This classification reflects both emerging aetiological evidence of the complex interactions between brain and body and the need to resolve the historical split between somatic and mental disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.