Evidence map›Paper›PMID 32121656›Full record

ArticleVaccines2020

Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen

Jasmin Fertey, Lea Bayer, Sophie Kähl, Rukiya M Haji, Anke Burger-Kentischer, Martin Thoma, Bastian Standfest, Jessy Schönfelder, Javier Portillo Casado, Frank-Holm Rögner and 3 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Low-Energy Electron Irradiation Inactivates Viruses in Serum and Maintains Growth-Promoting Properties in Cell Culture.Applied biosafety : journal of the American Biological Safety Association · 2025
    Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Jasmin FerteyFraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103 Leipzig, Germany.ORCID 0000-0001-5424-3807
Lea BayerFraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103 Leipzig, Germany.
Sophie KählInstitute of Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany.
Rukiya M HajiFraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103 Leipzig, Germany.
Anke Burger-KentischerFraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstrasse 12, 70569 Stuttgart, Germany.
Martin ThomaFraunhofer Institute for Manufacturing Engineering and Automation IPA, Nobelstrasse 12, 70569 Stuttgart, Germany.ORCID 0000-0001-8599-315X
Bastian StandfestFraunhofer Institute for Manufacturing Engineering and Automation IPA, Nobelstrasse 12, 70569 Stuttgart, Germany.
Jessy SchönfelderFraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, Winterbergstrasse 28, 01277 Dresden, Germany.
Javier Portillo CasadoFraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, Winterbergstrasse 28, 01277 Dresden, Germany.
Frank-Holm RögnerFraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, Winterbergstrasse 28, 01277 Dresden, Germany.ORCID 0000-0002-5071-0508
Christoph Georg BaumsInstitute of Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany.ORCID 0000-0001-9149-1615
Thomas GrunwaldFraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103 Leipzig, Germany.
Sebastian UlbertFraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103 Leipzig, Germany.ORCID 0000-0001-5910-3643
Fraunhofer Institute for Cell Therapy and Immunology · DEFraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology · DEFraunhofer Institute for Manufacturing Engineering and Automation · DELeipzig University · DEFraunhofer Institute for Interfacial Engineering and Biotechnology · DE

Funding

European Commission EFRE
6 · The paper itself

Abstract

Bacterial pathogens cause severe infections worldwide in livestock and in humans, and antibiotic resistance further increases the importance of prophylactic vaccines. Inactivated bacterial vaccines (bacterins) are usually produced via incubation of the pathogen with chemicals such as formaldehyde, which is time consuming and may cause loss of immunogenicity due to the modification of structural components. We evaluated low-energy electron irradiation (LEEI) as an alternative method to generate a bacterin.

Indexed as

bacterinelectron beaminactivation of bacterialow-energy electron irradiationRodentibacter

Identifiers

PMID32121656
PMCPMC7157226
OpenAlexW3009203747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.