Evidence map›Paper›PMID 32121608›Full record

ArticlePharmaceutics2020

Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery.

Gianfranco Decandia, Fabio Palumbo, Annalisa Treglia, Vincenza Armenise, Pietro Favia, Federico Baruzzi, Katrin Unger, Alberto Perrotta, Anna Maria Coclite

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Initiated Chemical Vapor Deposition Kinetics of Poly(4-aminostyrene).Frontiers in bioengineering and biotechnology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Gianfranco DecandiaDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy.
Fabio PalumboInstitute of Nanotechnology, National Research Council of Italy, c/o Department of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy.ORCID 0000-0002-7972-9819
Annalisa TregliaDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy.
Vincenza ArmeniseDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy.ORCID 0000-0002-1419-1528
Pietro FaviaDepartment of Chemistry, University of Bari Aldo Moro, Via Orabona 4, 70126 Bari, Italy.
Federico BaruzziInstitute of Sciences of Food Production, National Research Council of Italy, Via G. Amendola 122/O, 70126 Bari, Italy.ORCID 0000-0002-3586-2140
Katrin UngerInstitute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, Austria.
Alberto PerrottaInstitute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, Austria.
Anna Maria CocliteInstitute of Solid State Physics, NAWI Graz, Graz University of Technology, Petersgasse 16, 8010 Graz, Austria.ORCID 0000-0001-5562-9744
Graz University of Technology · ATUniversity of Bari Aldo Moro · ITNational Research Council · ITInstitute of Sciences of Food Production · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca PONa3_00369Regione Puglia Apulian Industrial Plasma Laboratory
6 · The paper itself

Abstract

A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

Indexed as

antibacterial testdrug deliveryinitiated chemical vapour depositionpoly(methyl methacrylate) (PMMA) copolymer

Identifiers

PMID32121608
PMCPMC7150873
OpenAlexW3009994002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.