ReviewMaterials (Basel, Switzerland)2020
Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties.
Review in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Antimicrobial additives in resin-based endodontic sealers: a scoping review of antimicrobial efficacy, physicochemical properties, and cytotoxicity.Frontiers in dental medicine · 2026Pooled it
- Development of a Nano-Hybrid Composite Using Bovine Hydroxyapatite and Montmorillonite for Endodontic Applications-An In Vitro Study.International endodontic journal · 2026Article
- Mesoporous Bioactive Glass Nanoparticle-Reinforced Calcium Silicate Sealer for Reduced Microleakage and Enhanced Antibacterial Performance.Journal of functional biomaterials · 2026Article
- Evaluation of three obturation techniques in 3D-printed models of oval canals with standardized prepared morphology: a micro-CT study.BMC oral health · 2025Article
- In Vitro Bioactivity and Cytotoxicity Assessment of Two Root Canal Sealers.Materials (Basel, Switzerland) · 2025Article
- A Modified Bioceramic Sealer with Dual Antibacterial Mechanisms.Bioengineering (Basel, Switzerland) · 2025Article
- Developing a novel therapeutic and bioactive resin-based root canal sealer incorporated with silver polydopamine-modified hydroxyapatite fillers.BMC oral health · 2025Article
- Injectable and Conductive Polyurethane Gel with Load-Responsive Antibiosis for Sustained Root Canal Disinfection.Gels (Basel, Switzerland) · 2025Article
- Effect of preparation design and endodontic access on fracture resistance of zirconia overlays in mandibular molars: An in vitro study.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025Article
- Article
- The impact of dimethylaminohexadecyl methacrylates on the physical and antibacterial properties of endodontic sealers.Frontiers in oral health · 2025Article
- Evaluation of the Radiopacity, pH, and Calcium Ion Release of Calcium Silicate and Epoxy Resin-based Endodontic Cements.Iranian endodontic journal · 2025Article
- A Comparison of Conventional Root Canal Sealers With Ones That Use Green Synthesized Nanoparticles for Antimicrobial Activity: Protocol for a Systematic Review.JMIR research protocols · 2024Article
- Unlocking the Potential of Silver Nanoparticles: From Synthesis to Versatile Bio-Applications.Pharmaceutics · 2024Review
- The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles.Molecules (Basel, Switzerland) · 2024Article
- Comparative analysis of an epoxy resin-based and a premixed calcium silicate-based sealer's push-out bond strength with and without incorporation of chitosan nanoparticles: AnJournal of conservative dentistry and endodontics · 2024Article
- Article
- Evaluation of cytotoxicity and adaptability of a novel bioceramic root canal sealer: AnJournal of conservative dentistry and endodontics · 2024Article
- Application of Nanomaterials in Endodontics.BME frontiers · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the American Dental Association Survey of Dental Services Rendered (published in 2007), 15 million root canal treatment procedures are performed annually. Endodontic therapy relies mainly on biomechanical preparation, chemical irrigation and intracanal medicaments which play an important role in eliminating bacteria in the root canal. Furthermore, adequate obturation is essential to confine any residual bacteria within the root canal and deprive them of nutrients. However, numerous studies have shown that complete elimination of bacteria is not achieved due to the complex anatomy of the root canal system. There are several conventional antibiotic materials available in the market for endodontic use. However, the majority of these antibiotics and antiseptics provide short-term antibacterial effects, and they impose a risk of developing antibacterial resistance. The root canal is a dynamic environment, and antibacterial and antibiofilm materials with long-term effects and nonspecific mechanisms of action are highly desirable in such environments. In addition, the application of acidic solutions to the root canal wall can alter the dentin structure, resulting in a weaker and more brittle dentin. Root canal sealers with bioactive properties come in direct contact with the dentin wall and can play a positive role in bacterial elimination and strengthening of the root structure. The new generation of nanostructured, bioactive, antibacterial and remineralizing additives into polymeric resin-based root canal sealers are discussed in this review. The effects of these novel bioactive additives on the physical and sealing properties, as well as their biocompatibility, are all important factors that are presented in this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.