ArticlePharmaceutics2020
Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
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- Innovative Topical Patches for Non-Melanoma Skin Cancer: Current Challenges and Key Formulation Considerations.Pharmaceutics · 2023Review
- Design, Development, and Evaluation of Treprostinil Embedded Adhesive Transdermal Patch.Pharmaceutics · 2023Article
- Influence of Acid-Modified Clinoptilolite on the Self-Adhesive Properties of Silicone Pressure-Sensitive Adhesives.Polymers · 2023Article
- Losartan Potassium and Verapamil Hydrochloride Compound Transdermal Drug Delivery System: Formulation and Characterization.International journal of molecular sciences · 2022Article
- Formulation and Evaluation of a Drug-in-Adhesive Patch for Transdermal Delivery of Colchicine.Pharmaceutics · 2022Article
- Influence of Silicone Additives on the Properties of Pressure-Sensitive Adhesives.Materials (Basel, Switzerland) · 2022Article
- Article
- Microneedle and iontophoresis mediated delivery of methotrexate into and across healthy and psoriatic skin.International journal of pharmaceutics · 2022Article
- Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil Transdermal Patches.Pharmaceutics · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly affect the permeation, release, and performance characteristics of the system. In this study we aimed to design and characterize transdermal delivery systems formulated with lidocaine-as the model drug-loaded in different PSAs, including silicone, polyisobutylene (PIB), and acrylate. TDS containing lidocaine at its saturation points were prepared by the solvent casting method. In vitro permeation studies across dermatomed porcine ear skin were performed using Franz diffusion cells. In vitro release studies were carried out using USP apparatus 5 (paddle over disk). The cumulative amount permeated from the acrylate was significantly higher than silicone and PIB. The acrylate TDS contained a ten times higher drug amount than silicone TDS, but the permeation flux was only two folds higher. Results also showed the release of drug does not linearly correlate to saturation, as the silicone TDS comprising of the lowest amount of drug loading, showed the highest percentage release indicating the choice of PSA affected the drug release and permeation profile.
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