Evidence map›Paper›PMID 32121467›Full record

SynthesisGenes2020

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.

Emmanuel O Adewuyi, Yadav Sapkota, International Endogene Consortium Iec, andMe Research Team, International Headache Genetics Consortium Ihgc, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R Griffiths, Grant W Montgomery and 2 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  10. Article
  11. Predictive markers of endometriosis: a future perspective.Archives of gynecology and obstetrics · 2026
    Review
  12. Article
  13. Article
  14. Polymorphism of theLife (Basel, Switzerland) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emmanuel O AdewuyiSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Yadav SapkotaDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
International Endogene Consortium Iec
andMe Research Team23andMe, Inc., 899 W. Evelyn Avenue, Mountain View, California 94041, USA.
International Headache Genetics Consortium Ihgc
Asa AutaSchool of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
Kosuke YoshiharaDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 950-2181, Japan.
Mette NyegaardDepartment of Biomedicine - Human Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
Lyn R GriffithsSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Daniel I ChasmanDivisions of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Dale R NyholtSchool of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Funding

Wellcome Trust WT084766/Z/08/Z, (awards 076113 and 085475)
6 · The paper itself

Abstract

Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (

Indexed as

Genetic Predisposition to DiseaseAdultAgedComorbidityEndometriosisFemaleGenome-Wide Association StudyHumansLinkage DisequilibriumMendelian Randomization AnalysisMiddle AgedMigraine DisordersPhenotypePhosphatidylinositol 3-KinasesPolymorphism, Single NucleotideRisk FactorsPhosphatidylinositol 3-Kinasescausalitycomorbidityendometriosisgene-based association studygenetic overlapGWASMendelian randomisationmigrainemolecular geneticspathway enrichment study

Identifiers

PMID32121467
PMCPMC7140889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.