Evidence map›Paper›PMID 32121236›Full record

Trial reportNutrients2020

Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study

Hajar Mazahery, Cathryn A Conlon, Kathryn L Beck, Owen Mugridge, Marlena C Kruger, Welma Stonehouse, Carlos A Camargo, Barbara J Meyer, Bobby Tsang, Pamela R von Hurst

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Effects of Vitamin D Supplementation on Children with Autism Spectrum Disorder: A Systematic Review and Meta-analysis.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023
    Review
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Hajar MazaherySchool of Sport, Exercise and Nutrition, College of Health, Massey University, Auckland 0745, New Zealand.
Cathryn A ConlonSchool of Sport, Exercise and Nutrition, College of Health, Massey University, Auckland 0745, New Zealand.
Kathryn L BeckSchool of Sport, Exercise and Nutrition, College of Health, Massey University, Auckland 0745, New Zealand.
Owen MugridgeSchool of Sport, Exercise and Nutrition, College of Health, Massey University, Auckland 0745, New Zealand.
Marlena C KrugerSchool of Health Sciences, College of Health, Massey University, Palmerston North 4442, New Zealand.
Welma StonehouseCommonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide SA 5000, Australia.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Barbara J MeyerSchool of Medicine, Lipid Research Centre, Molecular Horizons, University of Wollongong, Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Bobby TsangDepartment of Paediatrics, Child and Youth Health, University of Auckland, Auckland 1023, New Zealand.
Pamela R von HurstSchool of Sport, Exercise and Nutrition, College of Health, Massey University, Auckland 0745, New Zealand.
Massey University · NZCommonwealth Scientific and Industrial Research Organisation · AUHarvard University · USRiddet Institute · NZUniversity of Auckland · NZUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of vitamin D and omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA) in improving core symptoms of autism spectrum disorder (ASD) in children has been investigated by a few randomised controlled trials and the results are mixed and inconclusive. The response to treatment with these nutrients is heterogenous and may be influenced by inflammatory state. As an exploratory analysis, we investigated whether inflammatory state would modulate the effect of these nutrients on core symptoms of ASD. Methods

resultsWe found evidence for an interaction between baseline IL-1β and treatment response for SRS-total, SRS-social communicative functioning, SRS-awareness and SRS-communication (all

conclusionInflammatory state may have modulated responses to vitamin D and omega-3 LCPUFA intervention in children with ASD, suggesting children with elevated inflammation may benefit more from daily vitamin D and omega-3 LCPUFA supplementation.

Indexed as

Autism Spectrum DisorderChildChild, PreschoolFatty Acids, Omega-3FemaleHumansInflammationInterleukin-1betaMalePilot ProjectsSurveys and QuestionnairesVitamin DFatty Acids, Omega-3Interleukin-1betaVitamin Dautisminflammationinterleukin 1interventionomega-3vitamin D

Identifiers

PMID32121236
PMCPMC7146497
OpenAlexW3010542713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.