Evidence map›Paper›PMID 32121196›Full record

ReviewMarine drugs2020

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa.

Justus Amuche Nweze, Florence N Mbaoji, Gang Huang, Yanming Li, Liyan Yang, Yunkai Zhang, Shushi Huang, Lixia Pan, Dengfeng Yang

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Marine-DerivedInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Isolation of a novel marineJournal of biosciences · 2025
    Article
  7. Review
  8. Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Oxidative Cyclization atMarine drugs · 2023
    Article
  14. MarineMarine drugs · 2023
    Review
  15. β-Lactams from the Ocean.Marine drugs · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Justus Amuche NwezeGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.ORCID 0000-0003-3481-040X
Florence N MbaojiGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.
Gang HuangGuangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.
Yanming LiGuangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.
Liyan YangGuangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.
Yunkai ZhangCollege of Life Science and Technology of Guangxi University, Nanning 530004, Guangxi, China.
Shushi HuangGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.
Lixia PanGuangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.
Dengfeng YangGuangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.ORCID 0000-0003-0596-6157
Guangxi Academy of Sciences · CNUniversity of Nigeria · NGGuangxi University · CN

Funding

National Natural Science Foundation of China Grant No. 31560017, 31660251, 31860245 and 31960203Natural Science Foundation of Guangxi Province Grant No. 2017GXNSFAA198010, 2018GXNSFAA138024 and 2018GXNSFAA281019Special Project for the Base of Guangxi Science and Technology and Talents No. AD17129019the central government directs special funds for local science and technology development projects ZY1949015
6 · The paper itself

Abstract

As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

Indexed as

Aquatic OrganismsDrug ResistanceAnimalsAnti-Bacterial AgentsBiological ProductsOceans and SeasAnti-Bacterial AgentsBiological Productsalgae invertebrates.antimicrobialsbacteriadrug-resistantfungimarinenatural products

Identifiers

PMID32121196
PMCPMC7142797
OpenAlexW3010428198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.