Evidence map›Paper›PMID 32121172›Full record

ArticleMicromachines2020

Towards PCB-Based Miniaturized Thermocyclers for DNA Amplification.

Georgia D Kaprou, Vasileios Papadopoulos, Christos-Moritz Loukas, George Kokkoris, Angeliki Tserepi

Abstract read
In one paragraph

Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Innovative Quantification of Critical Quality Attributes.Advances in experimental medicine and biology · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Georgia D KaprouInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Gregoriou E' and 27 Neapoleos str., 15341 Aghia Paraskevi, Attiki, Greece.
Vasileios PapadopoulosInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Gregoriou E' and 27 Neapoleos str., 15341 Aghia Paraskevi, Attiki, Greece.
Christos-Moritz LoukasInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Gregoriou E' and 27 Neapoleos str., 15341 Aghia Paraskevi, Attiki, Greece.
George KokkorisInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Gregoriou E' and 27 Neapoleos str., 15341 Aghia Paraskevi, Attiki, Greece.
Angeliki TserepiInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Patr. Gregoriou E' and 27 Neapoleos str., 15341 Aghia Paraskevi, Attiki, Greece.

Funding

European Commission 68768
6 · The paper itself

Abstract

In recent years, printed circuit board (PCB)-based microfluidics have been explored as a means to achieve standardization, seamless integration, and large-scale manufacturing of microfluidics, thus paving the way for widespread commercialization of developed prototypes. In this work, static micro polymerase chain reaction (microPCR) devices comprising resistive microheaters integrated on PCBs are introduced as miniaturized thermocyclers for efficient DNA amplification. Their performance is compared to that of conventional thermocyclers, in terms of amplification efficiency, power consumption and duration. Exhibiting similar efficiency to conventional thermocyclers, PCB-based miniaturized thermocycling achieves faster DNA amplification, with significantly smaller power consumption. Simulations guide the design of such devices and propose means for further improvement of their performance.

Indexed as

genomic Salmonella DNAmicrofluidicsmicro polymerase chain reaction (microPCR)multi-well PCRprinted circuit board (PCB)simulationstatic

Identifiers

PMID32121172
PMCPMC7143664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.