ArticleBiomolecules2020
A Comprehensive Comparison of Bovine and Porcine Decellularized Pericardia: New Insights for Surgical Applications.
Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 63 citations in OpenAlex.
- Identification of Autologous Tissue Sources and Optimization of a Treatment Method for Intraoperative Manufacturing of Heart Valve Constructs.Artificial organs · 2026Article
- A New Cardiac Decellularized Extracellular Matrix (dECM)-Based Hydrogel: From Its Development with a Standardized Myocardial Decellularization Procedure to In Vitro Model Applications.Gels (Basel, Switzerland) · 2026Article
- The Role and Involvement of Functional Three-Dimensional Porcine-Derived Collagen Matrix Biomaterials in Periodontal Regeneration: A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Tissue engineered decellularized bovine pericardium as prosthetic material in paediatric cardiac surgery.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Recent advances in pericardium extracellular matrix for tissue regeneration, along with a short insight into artificial intelligence.Frontiers in medical technology · 2025Review
- The Potential of a New Natural Vessel Source: Decellularized Intercostal Arteries as Sufficiently Long Small-Diameter Vascular Grafts.Bioengineering (Basel, Switzerland) · 2024Article
- Impact of the Different Chemical-Based Decellularization Protocols on the Properties of the Caprine Pericardium.Cardiovascular engineering and technology · 2024Article
- Hybrid Materials for Vascular Applications: A Preliminary In Vitro Assessment.Bioengineering (Basel, Switzerland) · 2024Article
- Tissue-engineered and autologous pericardium in congenital heart surgery: comparative histopathological study of human vascular explants.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Article
- Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy.Bioactive materials · 2024Review
- Characterisation of Matrix-Bound Nanovesicles (MBVs) Isolated from Decellularised Bovine Pericardium: New Frontiers in Regenerative Medicine.International journal of molecular sciences · 2024Article
- Geometrically modified bovine pericardium membrane promotes the expression of molecules targeted for a faster integration and vascularization process.Frontiers in bioengineering and biotechnology · 2024Article
- Viability of Collagen Matrix Grafts Associated with Nanohydroxyapatite and Elastin in Bone Repair in the Experimental Condition of Ovariectomy.International journal of molecular sciences · 2023Article
- A Glutaraldehyde-Free Crosslinking Method for the Treatment of Collagen-Based Biomaterials for Clinical Application.Bioengineering (Basel, Switzerland) · 2023Article
- Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications.Pharmaceutics · 2023Article
- Preliminary In Vitro Assessment of Decellularized Porcine Descending Aorta for Clinical Purposes.Journal of functional biomaterials · 2023Article
- Development of Scaffolds from Bio-Based Natural Materials for Tissue Regeneration Applications: A Review.Gels (Basel, Switzerland) · 2023Review
- A comparative study of human and porcine-derived decellularised nerve matrices.Biomaterials translational · 2023Article
- In vitro evaluation of crosslinked bovine pericardium as potential scaffold for the oral cavity.Bio-medical materials and engineering · 2023Article
- Mid-term performance of decellularized equine pericardium in congenital heart surgery.Interactive cardiovascular and thoracic surgery · 2022Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 3 countries.
Funding
Abstract
Xenogeneic pericardium-based substitutes are employed for several surgical indications after chemical shielding, limiting their biocompatibility and therapeutic durability. Adverse responses to these replacements might be prevented by tissue decellularization, ideally removing cells and preserving the original extracellular matrix (ECM). The aim of this study was to compare the mostly applied pericardia in clinics, i.e. bovine and porcine tissues, after their decellularization, and obtain new insights for their possible surgical use. Bovine and porcine pericardia were submitted to TRICOL decellularization, based on osmotic shock, detergents and nuclease treatment. TRICOL procedure resulted in being effective in cell removal and preservation of ECM architecture of both species' scaffolds. Collagen and elastin were retained but glycosaminoglycans were reduced, significantly for bovine scaffolds. Tissue hydration was varied by decellularization, with a rise for bovine pericardia and a decrease for porcine ones. TRICOL significantly increased porcine pericardial thickness, while a non-significant reduction was observed for the bovine counterpart. The protein secondary structure and thermal denaturation profile of both species' scaffolds were unaltered. Both pericardial tissues showed augmented biomechanical compliance after decellularization. The ECM bioactivity of bovine and porcine pericardia was unaffected by decellularization, sustaining viability and proliferation of human mesenchymal stem cells and endothelial cells. In conclusion, decellularized bovine and porcine pericardia demonstrate possessing the characteristics that are suitable for the creation of novel scaffolds for reconstruction or replacement: differences in water content, thickness and glycosaminoglycans might influence some of their biomechanical properties and, hence, their indication for surgical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.