Evidence map›Paper›PMID 32121153›Full record

ArticleJournal of clinical medicine2020

Specialized Management of Oral Anticoagulation Therapy Improves Outcome in Patients with Chronic Renal Insufficiency.

Michael Lauterbach, Eduard Uhrich, Lisa Eggebrecht, Sebastian Göbel, Marina Panova-Noeva, Markus Nagler, Vincent Ten Cate, Christoph Bickel, Christine Espinola-Klein, Thomas Münzel and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01809015 (A Study Programme for the Evaluation of Oral Anticoagulation Therapy With Vitamin K Antagonists), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01809015 completednot on this map

A Study Programme for the Evaluation of Oral Anticoagulation Therapy With Vitamin K Antagonists

TypeobservationalSponsorJohannes Gutenberg University MainzRan2011 to 2018Enrolled2,318ConditionsAnticoagulant Antagonists, Vitamin K and Other Coagulants Causing Adverse Effects in Therapeutic Use, Atrial Fibrillation, Venous Thromboembolism
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Michael Lauterbach3rd Medical Clinic-Cardiology, Barmherzige Brüder Hospital, 54292 Trier, Germany.
Eduard Uhrich3rd Medical Clinic-Cardiology, Barmherzige Brüder Hospital, 54292 Trier, Germany.
Lisa EggebrechtPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Sebastian GöbelCardiology I, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Marina Panova-NoevaCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Markus NaglerPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Vincent Ten CatePreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Christoph BickelDepartment of Medicine I, Federal Armed Forces Central Hospital Koblenz, 56072 Koblenz, Germany.
Christine Espinola-KleinCardiology I, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Thomas MünzelCardiology I, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Philipp S WildPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Jürgen H ProchaskaPreventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Johannes Gutenberg University Mainz · DEBundeswehrzentralkrankenhaus Koblenz · DEKrankenhaus der Barmherzigen Brüder Trier · DE

Funding

Bayer Vital GmbH -Boehringer Ingelheim Pharma GmbH & Co. KG -Bundesministerium für Gesundheit BMBF 10E01003Center for Translational Vascular Biology, University Medical Center Mainz, Germany -Daiichi Sankyo Europe GmbH -Deutsche Herzstiftung -IMO Institute GmbH -Ministries of Health and Economics, Rhineland-Palatinate, Germany AZ.623.1Portavita BV -Sanofi-Aventis Germany GmbH -
6 · The paper itself

Abstract

Oral anticoagulation (OAC) is effective at preventing and treating thromboses and thromboembolism in patients with normal renal function. We aimed to research the impact of severe renal failure (RF) on patient outcome and to determine the potential benefit of caring for these patients in a specialized coagulation service (CS). A total of 1516 usual medical care patients and 756 CS-managed patients of the thrombEVAL multicenter (21 centers), prospective, cohort study (NCT01809015) were analyzed in a 3-year follow-up. Patients with RF (serum creatinine >3 mg/dL, no renal replacement therapy) were compared to patients without RF in usual care and a CS. The fluctuations in the international normalized ratios were significantly lower in CS-managed patients, and regardless of treatment in usual care or a CS, the time in therapeutic range was significantly lower in RF patients. Cox regression-adjusted hazard ratios for long-term outcome (1.5, 95% CI: 1.22-1.83,

Indexed as

adverse eventschronic kidney diseasecoagulation serviceoral anticoagulationvitamin K-antagonists

Identifiers

PMID32121153
PMCPMC7141283
OpenAlexW3010579220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.