Evidence map›Paper›PMID 32121123›Full record

ArticleAnimals : an open access journal from MDPI2020

Cognitive Abilities of Dogs with Mucopolysaccharidosis I: Learning and Memory.

Lena Provoost, Carlo Siracusa, Darko Stefanovski, Yan Che, Mingyao Li, Margret Casal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Differences in MPS I and MPS II Disease Manifestations.International journal of molecular sciences · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lena ProvoostSmall Animal Behavior Service, Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA 19104, USA.
Carlo SiracusaSmall Animal Behavior Service, Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA 19104, USA.
Darko StefanovskiDepartment of Clinical Sciences and Advanced Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA.
Yan CheGene Therapy Program, Department of Medicine, The Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.
Mingyao LiDepartment of Biostatistics and Epidemiology, The Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.
Margret CasalSection of Medical Genetics, Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

Gene Therapy of Mucopolysaccharidosis VIIR01DK054481 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CASAL, MARGRET L · 1998 to 2017
$7.0M
Improved Therapies from the Orphan Disease Center : MPS I-15-001-01/02 NIH NIDDK : 054481NIDDK NIH HHS R01 DK054481
6 · The paper itself

Abstract

Mucopolysaccharidosis I (MPS I) results from a deficiency of a lysosomal enzyme, alpha-L-iduronidase (IDUA). IDUA deficiency leads to glycosaminoglycan (GAG) accumulation resulting in cellular degeneration and multi-organ dysfunction. The primary aims of this pilot study were to determine the feasibility of cognitive testing MPS I affected dogs and to determine their non-social cognitive abilities with and without gene therapy. Fourteen dogs were tested: 5 MPS I untreated, 5 MPS I treated, and 4 clinically normal. The treated group received intrathecal gene therapy as neonates to replace the

Indexed as

cognitiondoglearningmemoryMPS I

Identifiers

PMID32121123
PMCPMC7143070
OpenAlexW3009340445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.