Evidence map›Paper›PMID 32121065›Full record

ReviewCells2020

Relationship between Heart Disease and Liver Disease: A Two-Way Street.

Hamza El Hadi, Angelo Di Vincenzo, Roberto Vettor, Marco Rossato

Registry-linked trialAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07144501 (Prevalence of Liver Dysfunction in Paediatric Patients With Congenital Heart Disease), which is not on this map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07144501 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Prevalence of Liver Dysfunction in Paediatric Patients With Congenital Heart Disease: A Cross-Sectional Study at Assiut University Children Hospital.

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled40ConditionsCongenital Heart Disease, Liver DysfunctionArmsUltrasonography, Blood Sampling
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Alcohol consumption and heart failure: a dose-response meta-analysis.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Combined heart and liver transplantation: an updated systematic review.Annals of the Royal College of Surgeons of England · 2022
    Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Review
  7. Echocardiography, Bile Acids and Spleen Stiffness to Rule Out High-Risk Varices in Children With Biliary Atresia.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
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  19. Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hamza El HadiInternal Medicine 3, Department of Medicine - DIMED, University of Padova, Via Giustiniani2, 35100 Padova, Italy.
Angelo Di VincenzoInternal Medicine 3, Department of Medicine - DIMED, University of Padova, Via Giustiniani2, 35100 Padova, Italy.
Roberto VettorInternal Medicine 3, Department of Medicine - DIMED, University of Padova, Via Giustiniani2, 35100 Padova, Italy.
Marco RossatoInternal Medicine 3, Department of Medicine - DIMED, University of Padova, Via Giustiniani2, 35100 Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In clinical practice, combined heart and liver dysfunctions coexist in the setting of the main heart and liver diseases because of complex cardiohepatic interactions. It is becoming increasingly crucial to identify these interactions between heart and liver in order to ensure an effective management of patients with heart or liver disease to provide an improvement in overall prognosis and therapy. In this review, we aim to summarize the cross-talk between heart and liver in the setting of the main pathologic conditions affecting these organs. Accordingly, we present the clinical manifestation, biochemical profiles, and histological findings of cardiogenic ischemic hepatitis and congestive hepatopathy due to acute and chronic heart failure, respectively. In addition, we discuss the main features of cardiac dysfunction in the setting of liver cirrhosis, nonalcoholic fatty liver disease, and those following liver transplantation.

Indexed as

AnimalsHeart DiseasesHumansLiverLiver DiseasesModels, BiologicalMyocardiumarrhythmiacardiogenic ischemic hepatitiscirrhotic cardiomyopathycongestive hepatopathyheart failureliver transplantationnonalcoholic fatty liver disease

Identifiers

PMID32121065
PMCPMC7140474

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.