ReviewJournal of clinical medicine2020
Perioperative Hyperoxyphobia: Justified or Not? Benefits and Harms of Hyperoxia during Surgery.
Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Restrictive versus liberal oxygenation in patients undergoing cardiopulmonary bypass-assisted heart surgery: a randomised controlled trial.British journal of anaesthesia · 2025Trial
- Association Between Intraoperative Arterial Oxygen Tension and Postoperative Opioid Consumption: A Large-Scale Cohort Study Using Overlap Weighting Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- A pilot comparative study of intraoperative results and surgical outcomes between asleep-awake-asleep and general anesthesia modalities in temporal lobe resections.Neurosurgical review · 2026Article
- Individual and combined effects of chemical and mechanical power on postoperative pulmonary complications: a secondary analysis of the REPEAT study.Anaesthesia · 2025Article
- Comparing supervised machine learning algorithms for the prediction of partial arterial pressure of oxygen during craniotomy.BMC medical informatics and decision making · 2025Article
- HIF-1α Pathway in COVID-19: A Scoping Review of Its Modulation and Related Treatments.International journal of molecular sciences · 2025Article
- Effects of intraoperative hyperoxia on cerebral blood flow and dynamic cerebral autoregulation.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- Current Approaches on Nurse-Performed Interventions to Prevent Healthcare-Acquired Infections: An Umbrella Review.Microorganisms · 2025Review
- Addressing researcher degrees of freedom through minP adjustment.BMC medical research methodology · 2024Article
- Higher fraction of inspired oxygen during anesthesia increase the risk of postoperative pulmonary complications in patients undergoing non-cardiothoracic surgery: a retrospective cohort study.Frontiers in physiology · 2024Article
- Article
- Practice of oxygen use in anesthesiology - a survey of the European Society of Anaesthesiology and Intensive Care.BMC anesthesiology · 2022Article
- Dangers of hyperoxia.Critical care (London, England) · 2021Review
- Exploring Hyperoxia Effects in Cancer-From Perioperative Clinical Data to Potential Molecular Mechanisms.Biomedicines · 2021Review
- Target arterial POAnnals of intensive care · 2021Review
- Differential Response of Pentanal and Hexanal Exhalation to Supplemental Oxygen and Mechanical Ventilation in Rats.Molecules (Basel, Switzerland) · 2021Article
- Revisited Hyperoxia Pathophysiology in the Perioperative Setting: A Narrative Review.Frontiers in medicine · 2021Review
- Prevention of Prosthetic Joint Infection: From Traditional Approaches towards Quality Improvement and Data Mining.Journal of clinical medicine · 2020Review
- Oxygen administration for postoperative surgical patients: a narrative review.Journal of intensive care · 2020Review
- Investigating Disturbances of Oxygen Homeostasis: From Cellular Mechanisms to the Clinical Practice.Frontiers in physiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of an inspiratory oxygen fraction of 0.80 during surgery is a topic of ongoing debate. Opponents claim that increased oxidative stress, atelectasis, and impaired oxygen delivery due to hyperoxic vasoconstriction are detrimental. Proponents point to the beneficial effects on the incidence of surgical site infections and postoperative nausea and vomiting. Also, hyperoxygenation is thought to extend the safety margin in case of acute intraoperative emergencies. This review provides a comprehensive risk-benefit analysis for the use of perioperative hyperoxia in noncritically ill adults based on clinical evidence and supported by physiological deduction where needed. Data from the field of hyperbaric medicine, as a model of extreme hyperoxygenation, are extrapolated to the perioperative setting. We ultimately conclude that current evidence is in favour of hyperoxia in noncritically ill intubated adult surgical patients.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.