ArticleMolecules (Basel, Switzerland)2020
Design of Deep Eutectic Systems: A Simple Approach for Preselecting Eutectic Mixture Constituents.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- π-low transition temperature mixtures with widely-tunable polarity and ultralow viscosity for synthesizing chiral nanomaterials.Nature communications · 2026Article
- Shelf life and time-resolved thermal, chemical, and thermodynamic characterization of four hydrophobic deep eutectic solvents.RSC advances · 2026Article
- Novel liquid-based approaches for transmucosal drug delivery.Acta pharmaceutica Sinica. B · 2026Review
- Deep Eutectic Solvents Formed by Complex Hydrides: A New Class of Hydrogen-Rich Liquid.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Prediction of speed of sound of deep eutectic solvents using artificial neural network coupled with group contribution approach.Scientific reports · 2025Article
- New Horizon in Selective Tocols Extraction from Deodorizer Distillates Under Mild Conditions by Using Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2025Review
- Tailoring the Solvation of Aqueous Zinc Electrolytes by Balancing Kosmotropic and Chaotropic Ions.ACS nano · 2025Article
- Recent Progress on Green New Phase Extraction and Preparation of Polyphenols in Edible Oil.Molecules (Basel, Switzerland) · 2023Review
- Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery.Pharmaceutics · 2022Review
- Design of Deep Eutectic Systems: Plastic Crystalline Materials as Constituents.Molecules (Basel, Switzerland) · 2022Article
- DES-Based Biocatalysis as a Green Alternative for the l-menthyl Ester Production Based on l-menthol Acylation.Molecules (Basel, Switzerland) · 2022Article
- Lopinavir-menthol co-crystals for enhanced dissolution rate and intestinal absorption.Journal of drug delivery science and technology · 2022Article
- Carbon Dioxide Solubility in Nonionic Deep Eutectic Solvents Containing Phenolic Alcohols.Frontiers in chemistry · 2022Article
- Influence of the Molecular Structure of Constituents and Liquid Phase Non-Ideality on the Viscosity of Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2021Article
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3 authors.
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Abstract
Eutectic systems offer a wide range of new (green) designer solvents for diverse applications. However, due to the large pool of possible compounds, selecting compounds that form eutectic systems is not straightforward. In this study, a simple approach for preselecting possible candidates from a pool of substances sharing the same chemical functionality was presented. First, the melting entropy of single compounds was correlated with their molecular structure to calculate their melting enthalpy. Subsequently, the eutectic temperature of the screened binary systems was qualitatively predicted, and the systems were ordered according to the depth of the eutectic temperature. The approach was demonstrated for six hydrophobic eutectic systems composed of L-menthol and monocarboxylic acids with linear and cyclic structures. It was found that the melting entropy of compounds sharing the same functionality could be well correlated with their molecular structures. As a result, when the two acids had a similar melting temperature, the melting enthalpy of a rigid acid was found to be lower than that of a flexible acid. It was demonstrated that compounds with more rigid molecular structures could form deeper eutectics. The proposed approach could decrease the experimental efforts required to design deep eutectic solvents, particularly when the melting enthalpy of pure components is not available.
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