Evidence map›Paper›PMID 32121033›Full record

ArticleJournal of clinical medicine2020

Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients.

Michael Koziolek, Gerhard A Mueller, Gry H Dihazi, Klaus Jung, Constanze Altubar, Manuel Wallbach, Ivana Markovic, Dirk Raddatz, Olaf Jahn, Hülya Karaköse and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Screening candidate diagnostic biomarkers for diabetic kidney disease.Journal of clinical laboratory analysis · 2024
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Michael KoziolekClinic for Nephrology and Rheumatology, University Medical Center Göttingen 1, 37075 Göttingen, Germany.
Gerhard A MuellerClinic for Nephrology and Rheumatology, University Medical Center Göttingen 1, 37075 Göttingen, Germany.
Gry H DihaziInstitute for Clinical Chemistry/UMG-Laboratories, University Medical Center Göttingen, 37075 Göttingen, Germany.
Klaus JungInstitute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Constanze AltubarClinic for Nephrology and Rheumatology, University Medical Center Göttingen 1, 37075 Göttingen, Germany.
Manuel WallbachClinic for Nephrology and Rheumatology, University Medical Center Göttingen 1, 37075 Göttingen, Germany.ORCID 0000-0002-1162-4682
Ivana MarkovicInstitute for Clinical Chemistry/UMG-Laboratories, University Medical Center Göttingen, 37075 Göttingen, Germany.
Dirk RaddatzClinic for Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Olaf JahnProteomics Group, Max-Planck-Institute of Experimental Medicine, 37075 Göttingen, Germany.ORCID 0000-0002-3397-8924
Hülya KaraköseClinic for Nephrology and Rheumatology, University Medical Center Göttingen 1, 37075 Göttingen, Germany.ORCID 0000-0002-0667-9718
Christof LenzInstitute for Clinical Chemistry/UMG-Laboratories, University Medical Center Göttingen, 37075 Göttingen, Germany.
Henning UrlaubInstitute for Clinical Chemistry/UMG-Laboratories, University Medical Center Göttingen, 37075 Göttingen, Germany.
Abdelhi DihaziLaboratory of Biotechnology and Molecular Bioengineering, Faculty of Sciences and Techniques Gueliz, Cadi Ayyad University, Marrakech 40000, Morocco.
Abdellatif El MezianeLaboratory of Biotechnology and Molecular Bioengineering, Faculty of Sciences and Techniques Gueliz, Cadi Ayyad University, Marrakech 40000, Morocco.
Hassan DihaziClinic for Nephrology and Rheumatology, University Medical Center Göttingen 1, 37075 Göttingen, Germany.
Universitätsmedizin Göttingen · DECadi Ayyad University · MAMax Planck Institute of Experimental Medicine · DEUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

Bundesministerium für Bildung und Forschung 01DH17008
6 · The paper itself

Abstract

Diabetic nephropathy (DN) is the main reason for end-stage renal disease. Microalbuminuria as the non-invasive available diagnosis marker lacks specificity and gives high false positive rates. To identify and validate biomarkers for DN, we used in the present study urine samples from four patient groups: diabetes without nephropathy, diabetes with microalbuminuria, diabetes with macroalbuminuria and proteinuria without diabetes. For the longitudinal validation, we recruited 563 diabetic patients and collected 1363 urine samples with the clinical data during a follow-up of 6 years. Comparative urinary proteomics identified four proteins Apolipoprotein A-I (APOA1), Beta-2-microglobulin (B2M), E-cadherin (CDH1) and Lithostathine-1-alpha (REG1A), which differentiated with high statistical strength (

Indexed as

Diabetic nephropathyearly biomarkerearly diagnosis/prognosisE-cadherin

Identifiers

PMID32121033
PMCPMC7141221
OpenAlexW3010406649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.