Evidence map›Paper›PMID 32120995›Full record

ArticleInternational journal of molecular sciences2020

Alternatively Constructed Estrogen Receptor Alpha-Driven Super-Enhancers Result in Similar Gene Expression in Breast and Endometrial Cell Lines.

Dóra Bojcsuk, Gergely Nagy, Bálint László Bálint

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Targeting DNA Damage Response in Prostate and Breast Cancer.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dóra BojcsukGenomic Medicine and Bioinformatic Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Gergely NagyDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Bálint László BálintGenomic Medicine and Bioinformatic Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
University of Debrecen · HU

Funding

Debrecen Venture Catapult Program EFOP-3.6.1-16-2016-00022Hungarian Scientific Research Fund K 129166Hungarian Scientific Research Fund PD 124843MOLMEDEX FUN-OMICS GINOP-2.3.3-15-2016-00007New National Excellence Program of the Ministry of Human Capacities ÚNKP-17-3-IV-DE-140New National Excellence Program of the Ministry of Human Capacities ÚNKP-18-3-III-DE-253New National Excellence Program of the Ministry of Human Capacities ÚNKP-19-4-DE-173
6 · The paper itself

Abstract

Super-enhancers (SEs) are clusters of highly active enhancers, regulating cell type-specific and disease-related genes, including oncogenes. The individual regulatory regions within SEs might be simultaneously bound by different transcription factors (TFs) and co-regulators, which together establish a chromatin environment conducting to effective transcription. While cells with distinct TF profiles can have different functions, how different cells control overlapping genetic programs remains a question. In this paper, we show that the construction of estrogen receptor alpha-driven SEs is tissue-specific, both collaborating TFs and the active SE components greatly differ between human breast cancer-derived MCF-7 and endometrial cancer-derived Ishikawa cells; nonetheless, SEs common to both cell lines have similar transcriptional outputs. These results delineate that despite the existence of a combinatorial code allowing alternative SE construction, a single master regulator might be able to determine the overall activity of SEs.

Indexed as

Enhancer Elements, GeneticBasic Helix-Loop-Helix ProteinsBinding SitesBreast NeoplasmsCell Line, TumorChromatin Immunoprecipitation SequencingDNA-Binding ProteinsE-Box ElementsEndometrial NeoplasmsEndometriumEstrogen Receptor alphaFemaleForkhead Box Protein M1Gene Expression Regulation, NeoplasticHumansMCF-7 CellsBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsESR1 protein, humanEstrogen Receptor alphaForkhead Box Protein M1FOXM1 protein, humanMuscle ProteinsTCF12 protein, humanTEAD4 protein, humanTEA Domain Transcription FactorsTranscription FactorsChIP-seqenhancerestrogen receptor alpha (ERα), transcription factorIshikawa cell lineMCF-7 cell linesuper-enhancer

Identifiers

PMID32120995
PMCPMC7084573
OpenAlexW3008881943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.