Evidence map›Paper›PMID 32120994›Full record

ArticleNutrients2020

Probiotic Bacillus Spores Protect Against Acetaminophen Induced Acute Liver Injury in Rats.

Maria Adriana Neag, Adrian Catinean, Dana Maria Muntean, Maria Raluca Pop, Corina Ioana Bocsan, Emil Claudiu Botan, Anca Dana Buzoianu

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Convergence of Nanotechnology and Bacteriotherapy for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  9. Review
  10. Article
  11. Effects ofFrontiers in veterinary science · 2024
    Article
  12. The Effects of ProbioticInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Protective effects ofFrontiers in immunology · 2023
    Article
  18. Review
  19. DietaryFrontiers in microbiology · 2023
    Article
  20. Nutritional Support in Acute Liver Failure.Diseases (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria Adriana NeagDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Adrian CatineanDepartment of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Dana Maria MunteanDepartment of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania.
Maria Raluca PopDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Corina Ioana BocsanDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Emil Claudiu BotanCounty Emergency Hospital, 400006 Cluj-Napoca, Romania.
Anca Dana BuzoianuDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · ROClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP) is one of the most used analgesics and antipyretic agents in the world. Intoxication with APAP is the main cause of acute liver toxicity in both the US and Europe. Spore-forming probiotic bacteria have the ability to resist harsh gastric and intestinal conditions. The aim of this study was to investigate the possible protective effect of

Indexed as

BacillusSpores, BacterialAcetaminophenAlanine TransaminaseAnimalsAspartate AminotransferasesInterleukin-1betaLiverLiver Failure, AcuteMaleProbioticsRatsRats, WistarTumor Necrosis Factor-alphaZonula Occludens-1 ProteinAcetaminophenAlanine TransaminaseAspartate AminotransferasesIL1B protein, ratInterleukin-1betaTjp1 protein, ratTumor Necrosis Factor-alphaZonula Occludens-1 Proteinacetaminophenacute hepatotoxicityBacillus sporesinflammationtight junction

Identifiers

PMID32120994
PMCPMC7146158
OpenAlexW3006929350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.