Evidence map›Paper›PMID 32120976›Full record

ArticleMolecules (Basel, Switzerland)2020

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats.

Janet Olayemi Olugbodi, Oladipupo David, Ene Naomi Oketa, Bashir Lawal, Bamidele Joseph Okoli, Fanyana Mtunzi

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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  16. An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Janet Olayemi OlugbodiDepartment of Biochemistry, Bingham University, Abuja-Keffi expressway Road, P.M.B 005 Karu, Nigeria.ORCID 0000-0002-9134-8234
Oladipupo DavidDepartment of Medical Bioscience, University of the Western Cape, Bellville, Cape Town 7530, South Africa.ORCID 0000-0001-9190-8978
Ene Naomi OketaDepartment of Biochemistry, Bingham University, Abuja-Keffi expressway Road, P.M.B 005 Karu, Nigeria.
Bashir LawalPhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 111, Taiwan.ORCID 0000-0003-0676-5875
Bamidele Joseph OkoliInstitute of Chemical and Biotechnology, Vaal University of Technology, Science Park, Private Bag x021, South Africa.ORCID 0000-0001-7841-683X
Fanyana MtunziDIHLARE Remedy, Faculty of Applied and Computer Sciences, Vaal University of Technology, Science Park, Private Bag x021, South Africa.
Bingham University · NGVaal University of Technology · ZATaipei Medical University · TWUniversity of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV-visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.

Indexed as

AnimalsBloodCatalaseEpididymisErythrocytesFollicle Stimulating HormoneGlutathioneLuteinizing HormoneMaleMalondialdehydeMetal NanoparticlesMicroscopy, Electron, ScanningOxidative StressPeroxidesRatsSilverCatalaseFollicle Stimulating HormoneGlutathioneLuteinizing HormoneMalondialdehydePeroxidesSilverSuperoxide DismutaseTestosteroneantioxidantsepididymishormonessilver nanoparticlessperm parameterstestistoxicity

Identifiers

PMID32120976
PMCPMC7179123
OpenAlexW3009178154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.