Evidence map›Paper›PMID 32120974›Full record

ArticleGenes2020

Differential Dorsolateral Prefrontal Cortex Proteomic Profiles of Suicide Victims with Mood Disorders.

Alejandra Cabello-Arreola, Ada Man-Choi Ho, Aysegul Ozerdem, Alfredo B Cuellar-Barboza, Mehmet U Kucuker, Carrie J Heppelmann, M Cristine Charlesworth, Deniz Ceylan, Craig A Stockmeier, Grazyna Rajkowska and 3 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Alejandra Cabello-ArreolaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Ada Man-Choi HoDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Aysegul OzerdemDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Alfredo B Cuellar-BarbozaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Mehmet U KucukerDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Carrie J HeppelmannProteomics Core, Medical Genome Facility, Mayo Clinic, Rochester, MN 55905, USA.
M Cristine CharlesworthProteomics Core, Medical Genome Facility, Mayo Clinic, Rochester, MN 55905, USA.
Deniz CeylanIzmir University of Economics, Faculty of Medicine, Department of Psychiatry, Izmir 35330, Turkey.
Craig A StockmeierDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA.
Grazyna RajkowskaDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Doo-Sup ChoiDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Marin VeldicDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clinic · USJackson Memorial Hospital · USİzmir University of Economics · TR

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
Alcohol and Adenosine-Mediated Glutamate Signaling in Neuro-Glial InteractionR01AA018779 · NIAAA · MAYO CLINIC ROCHESTER · PI CHOI, DOO-SUP · 2009 to 2019
$3.8M
Postmortem Human Brain Collection (Supplement to MH67996)R01MH067996 · NIMH · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI STOCKMEIER, CRAIG ALLEN · 2004 to 2007
$1.2M
NIAAA NIH HHS AA018779NIGMS NIH HHS P20 GM121334NIGMS NIH HHS P30 GM103328NIMH NIH HHS R01 MH067996NIMH NIH HHS R01 MH67996
6 · The paper itself

Abstract

Suicide is a major public health concern; nevertheless, its neurobiology remains unknown. An area of interest in suicide research is the dorsolateral prefrontal cortex (DLPFC). We aimed to identify altered proteins and potential biological pathways in the DLPFC of individuals who died by suicide employing mass spectrometry-based untargeted proteomics. Postmortem DLPFC from age-matched male suicide mood disorder cases (n = 5) and non-suicide mood disorder cases (n = 5) were compared. The proteins that differed between groups at false discovery rate (FDR) adjusted p-values (Benjamini-Hochberg-Yekutieli) <0.3 and Log

Indexed as

SuicideFemaleHumansMaleMood DisordersPrefrontal CortexProteinsProteomicsProteinsbrainDLPFCGABAKCNQ3mood disorderspathwaysproteomicssuicide

Identifiers

PMID32120974
PMCPMC7140872
OpenAlexW3010129132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.