Evidence map›Paper›PMID 32120861›Full record

ArticleMolecules (Basel, Switzerland)2020

3-Aryl-4-nitrobenzothiochromans

Matteo Micucci, Maurizio Viale, Alberto Chiarini, Domenico Spinelli, Maria Frosini, Cinzia Tavani, Massimo Maccagno, Lara Bianchi, Rosaria Gangemi, Roberta Budriesi

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matteo MicucciDipartimento di Farmacia & Biotecnologia, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Maurizio VialeIRCCS Ospedale Policlinico San Martino, U.O. Bioterapie, L.go R. Benzi 10, 16132 Genova, Italy.
Alberto ChiariniDipartimento di Farmacia & Biotecnologia, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Domenico SpinelliDipartimento di Chimica "G. Ciamician", Alma Mater Studiorum-University of Bologna, via F. Selmi 2, 40126 Bologna, Italy.
Maria FrosiniDipartimento di Scienze della Vita, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy.
Cinzia TavaniDipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Via Dodecaneso 31, 16146 Genova, Italy.
Massimo MaccagnoDipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Via Dodecaneso 31, 16146 Genova, Italy.
Lara BianchiDipartimento di Chimica e Chimica Industriale, Università degli Studi di Genova, Via Dodecaneso 31, 16146 Genova, Italy.
Rosaria GangemiIRCCS Ospedale Policlinico San Martino, U.O. Bioterapie, L.go R. Benzi 10, 16132 Genova, Italy.
Roberta BudriesiDipartimento di Farmacia & Biotecnologia, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our research groups have been involved for many years in studies aimed at identifying new active organic compounds endowed with pharmacological properties. In this work, we focused our attention on the evaluation of cardiovascular and molecular drug resistance (MDR) reverting activities of some nitrosubstituted sulphur-containing heterocycles. Firstly, we have examined the effects of 4-nitro-3-(4-methylphenyl)-3,6-dihydro-2

Indexed as

AnimalsAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BCalcium ChannelsCell Line, TumorCell ProliferationChromansDoxorubicinDrug Resistance, MultipleDrug Resistance, NeoplasmDrug SynergismGuinea PigsHeart AtriaHumansInhibitory Concentration 50Muscle, SmoothABCB1 protein, humanAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BCalcium ChannelsChromansDoxorubicinPyransSulfhydryl CompoundsThiaminethiochromethiopyran3-aryl-4-nitrothiochromans S,S-dioxideanticancer therapycardiovascular activityin vitro experimentsl-Type Calcium Channels (LTCC)multidrug resistance (MDR1)

Identifiers

PMID32120861
PMCPMC7179187

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.