Evidence map›Paper›PMID 32120830›Full record

ArticleInternational journal of molecular sciences2020

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells.

Mingxi Jia, Wenjing Zhang, Taojin He, Meng Shu, Jing Deng, Jianhui Wang, Wen Li, Jie Bai, Qinlu Lin, Feijun Luo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A randomised control trial to compareJournal of research in nursing : JRN · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Interactions between Nanoparticles and Intestine.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Review
  19. Nano Silver-Induced Toxicity and Associated Mechanisms.International journal of nanomedicine · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mingxi JiaHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Wenjing ZhangHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Taojin HeHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Meng ShuHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Jing DengHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Jianhui WangSchool of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, China.
Wen LiHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Jie BaiHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Qinlu LinHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Feijun LuoHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Wenhua ZhouHunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, College of Food Science and Engineering, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha 410004, China.
Xiaoxi ZengKey Laboratory of Biological Nanomaterials and Devices, College of life sciences and chemistry, Hunan University of Technology, Zhuzhou 412007, China.
Central South University of Forestry and Technology · CNChangsha University of Science and Technology · CNHunan University of Technology · CN

Funding

Hunan Scientific Talents Promotion Program of Hunan Association for Science and Technology 2019TJ-Q01National Key R&D Program of China 2018YFE0110200 ,2015BAD05B02the key program of Hunan Provincial Department of science and technology 2016NK2096, 2019NK2111 ,2019SK2121the National Natural Science Foundation of China 51774128the Natural Science Foundation of Hunan Province of China 2018JJ4061, 2018JJ2090,2018JJ4009the Scientific Research Fund of Hunan Provincial Education Department 17A055 ,18B290
6 · The paper itself

Abstract

Nano Ag has excellent antibacterial properties and is widely used in various antibacterial materials, such as antibacterial medicine and medical devices, food packaging materials and antibacterial textiles. Despite the many benefits of nano-Ag, more and more research indicates that it may have potential biotoxic effects. Studies have shown that people who ingest nanoparticles by mouth have the highest uptake in the intestinal tract, and that the colon area is the most vulnerable to damage and causes the disease. In this study, we examined the toxic effects of different concentrations of Ag-NPs on normal human colon cells (NCM460) and human colon cancer cells (HCT116). As the concentration of nanoparticles increased, the activity of the two colon cells decreased and intracellular reactive oxygen species (ROS) increased. RT-qPCR and Western-blot analyses showed that Ag NPs can promote the increase in P38 protein phosphorylation levels in two colon cells and promote the expression of P53 and Bax. The analysis also showed that Ag NPs can promote the down-regulation of Bcl-2, leading to an increased Bax / Bcl-2 ratio and activation of P21, further accelerating cell death .This study showed that a low concentration of nano Ag has no obvious toxic effect on colon cells, while nano Ag with concentrations higher than 15 μg/mL will cause oxidative damage to colon cells.

Indexed as

Anti-Bacterial Agentsbcl-2-Associated X ProteinCell SurvivalCyclin-Dependent Kinase Inhibitor p21DNA DamageEpithelial CellsHCT116 CellsHumansMetal NanoparticlesMicroscopy, Electron, TransmissionOxidative Stressp38 Mitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesSilverAnti-Bacterial AgentsBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21p38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesSilverTP53 protein, humanTumor Suppressor Protein p53biological toxicitycolon cellsnano-Agoxidative damage

Identifiers

PMID32120830
PMCPMC7084348
OpenAlexW3008020986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.