Evidence map›Paper›PMID 32120827›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Oxidative Stress and Antioxidant Status in High-Risk Prostate Cancer Subjects.

Sanjeev Shukla, Janmejai K Srivastava, Eswar Shankar, Rajnee Kanwal, Akbar Nawab, Haripaul Sharma, Natarajan Bhaskaran, Lee E Ponsky, Pingfu Fu, Gregory T MacLennan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  5. Synergism of Specific Maca Phenotypes (Molecules (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sanjeev ShuklaDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Janmejai K SrivastavaDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Eswar ShankarDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Rajnee KanwalDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Akbar NawabDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Haripaul SharmaDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Natarajan BhaskaranDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Lee E PonskyDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Pingfu FuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Gregory T MacLennanThe Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Sanjay GuptaDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
University Hospitals of Cleveland · USCase Western Reserve University · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3M
Molecular Mechanisms of GSTP1 Reactivation by Green Tea PolyphenolsR01CA115491 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GUPTA, SANJAY · 2007 to 2011
$1.3M
NCI NIH HHS P30 CA43703NCI NIH HHS RO1CA115491, R21CA193080, R03CA186179U.S. Department of Veterans Affairs 1I01BX002494
6 · The paper itself

Abstract

The oxidant/antioxidant balance has been implicated in the pathophysiology of prostate cancer. We investigated oxidative damage and antioxidant status in high-risk prostate cancer subjects. Reduced glutathione (GSH) levels were measured in erythrocytes, 8-hydroxydeoxyguanosine (8-OHdG) in leukocytes and plasma levels of catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), glutathione S-transferase (GST), superoxide dismutase (SOD), and lipid peroxide products were measured in high-risk and age-matched healthy subjects. Serum PSA levels were significantly higher (

Indexed as

antioxidant enzymes 3DNA damage 4inflammation 2oxidative stress 1prostate cancer 5

Identifiers

PMID32120827
PMCPMC7151307
OpenAlexW3007175055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.