Evidence map›Paper›PMID 32120794›Full record

SynthesisNutrients2020

Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials.

Rui Nouchi, Takahiko Suiko, Eriko Kimura, Hiroki Takenaka, Michiaki Murakoshi, Akira Uchiyama, Megumi Aono, Ryuta Kawashima

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rui NouchiDepartment of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan.
Takahiko SuikoResearch and Development Headquarters, Lion Corporation, Edogawa, Tokyo 132-0035, Japan.
Eriko KimuraResearch and Development Headquarters, Lion Corporation, Edogawa, Tokyo 132-0035, Japan.
Hiroki TakenakaResearch and Development Headquarters, Lion Corporation, Edogawa, Tokyo 132-0035, Japan.
Michiaki MurakoshiResearch and Development Headquarters, Lion Corporation, Edogawa, Tokyo 132-0035, Japan.
Akira UchiyamaResearch and Development Headquarters, Lion Corporation, Edogawa, Tokyo 132-0035, Japan.
Megumi AonoResearch and Development Headquarters, Lion Corporation, Edogawa, Tokyo 132-0035, Japan.
Ryuta KawashimaSmart Aging Research Center (S.A.R.C.), Tohoku University, Seiryo-machi 4-1, Sendai 980-8575, Japan.
Lion Corporation (Japan) · JPTohoku University · JP

Funding

JSPS KAKENHI 16KT0002JSPS KAKENHI 19H01760Lion Corporation Lion Corporation
6 · The paper itself

Abstract

backgroundFruits and vegetables are generally rich in antioxidants such as carotenoids. Consumption of carotenoids is expected to have benefits on cognitive functions in humans. However, previous randomized controlled trials (RCT) using carotenoids have reported inconsistent results. Therefore, this systematic review (SR) aimed to summarize the effect of carotenoid intake on cognitive functions in humans.

methodPubMed, Cochrane Library, Web of Science, and PsychoINFO were searched for research papers on carotenoid intake with the criteria that 1) oral carotenoid intake was evaluated using RCTs, 2) participants were healthy young, middle-aged, or older, and 3) cognitive functions were measured using RCTs.

resultsFive studies using lutein and two studies using astaxanthin met the inclusion criteria. Consumption of lutein and its isomer showed consistent results in selective improvement of visual episodic memory in young and middle-aged adults while inhibition was observed in middle-aged and older adults. One of the two included astaxanthin studies reported a significant improvement of verbal episodic memory performance in middle-aged adults.

conclusionThis SR showed that the 10 mg lutein per day for twelve months can lead to improvement of cognitive functions. Due to the small number of studies, it is difficult to conclude whether astaxanthin would have a positive effect on cognitive functions.

Indexed as

AdultCognitionFemaleHumansLuteinMaleMemory, EpisodicMiddle AgedRandomized Controlled Trials as TopicXanthophyllsastaxanthineLuteinXanthophyllsastaxanthincarotenoidsepisodic memoryinhibitioninterventionlutein

Identifiers

PMID32120794
PMCPMC7146131
OpenAlexW3008839631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.