Evidence map›Paper›PMID 32120379›Full record

ArticlePediatric research2020

Electrocardiographic features at rest and during exercise in young adults born preterm below 30 weeks of gestation.

Anne-Sophie Gervais, Adrien Flahault, Tevy Chan, Camille Bastien-Tardif, Amy Al-Simaani, Anik Cloutier, Thuy Mai Luu, Sylvia Abadir, Anne-Monique Nuyt

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05243537 (QTc Intervals in Former Preterm/Extreme Low Birth Weight Infants), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05243537 unknown statusnot on this mapstarted 2023, after this paper: background citation

QTc Intervals in Former Preterm/Extreme Low Birth Weight Infants: a Pooled Study Proposal

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2023 to 2023Enrolled250ConditionsQt Interval, Preterm BirthArmsECG (diagnostic)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. The QTDrug safety · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anne-Sophie Gervais *Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Adrien Flahault *Sainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Tevy ChanSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Camille Bastien-TardifSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Amy Al-SimaaniSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Anik CloutierSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Thuy Mai LuuSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Sylvia AbadirSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada.
Anne-Monique NuytSainte-Justine University Hospital Research Center, University of Montreal, Montreal, QC, Canada. anne.monique.nuyt@umontreal.ca.
Université de Montréal · CAMontreal Heart Institute · CA

Funding

CIHR 133572
6 · The paper itself

Abstract

backgroundPreterm birth has adverse consequences on the cardiovascular system. Whether premature birth is associated with conduction and repolarisation abnormalities past childhood and into adulthood still needs to be demonstrated.

methodsWe analyzed the ECG of young adults (23.9 ± 3.1 years) born term (≥37 weeks, n = 53) and preterm (<30 weeks, n = 49) at rest, peak exercise and 3 min into recovery during an exercise test on a cycle ergometer. We measured PR, QRS and QT intervals, calculated the corrected QT (QTc), and determined blood calcium, magnesium, potassium and fasting glucose.

resultsMean gestational age was 39.7 ± 1.1 and 27.3 ± 1.3 weeks for the term and the preterm groups, respectively. Apart from an increased heart rate at rest in individuals born preterm, no significant difference was found between both groups for any other ECG parameters at rest. None of the participants had a severely prolonged QTc (>500 ms) at rest; exercise revealed severely prolonged QTc in two participants including one in the preterm group. The use of QT-prolonging medications did not influence ECG parameters in either groups.

conclusionsWe observed no significant difference in electrocardiographic measurements between young adults born preterm and term. Current results do not support avoidance of QT-prolonging medications in individuals born preterm. IMPACT: Preterm birth is associated with adverse cardiovascular consequences in early adulthood, but controversial evidence exists regarding differences in electrocardiographic features between young individuals born term and preterm.This study aims to assess the differences in electrocardiographic features between young adults born term and preterm, at rest and during exercise training.In contrast with previously published data, we observed no significant difference in electrocardiographic measurements between young adults born preterm and term.Our study does not support that preterm birth itself exposes young adults to a higher risk of QT prolongation.Current results do not support avoidance of QT-prolonging medications in individuals born preterm.

Indexed as

Cardiorespiratory FitnessElectrocardiographyExerciseHeart RateInfant, PrematurePremature BirthAdultExercise TestFemaleGestational AgeHumansInfant, NewbornLong QT SyndromeMalePredictive Value of TestsRisk Factors

Identifiers

PMID32120379
OpenAlexW3009762765

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.