Evidence map›Paper›PMID 32120304›Full record

ArticlePsychiatry research. Neuroimaging2020

Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children.

Célia Maria de Araújo, James Hudziak, Deana Crocetti, Nicholas F Wymbs, Janitza L Montalvo-Ortiz, Catherine Orr, Matthew D Albaugh, Robert R Althoff, Kerry O'Loughlin, Hannah Holbrook and 7 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03170362 (PRIME Care), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03170362 nacompletednot on this map

PRIME Care (PRecision Medicine In MEntal Health Care)

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2017 to 2022Enrolled1,944ConditionsMajor DepressionArmsPharmacogenetic Test
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Célia Maria de AraújoCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, United States; Universidade Federal de São Paulo, São Paulo, Brazil.
James HudziakVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Deana CrocettiCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, United States.
Nicholas F WymbsCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, United States.
Janitza L Montalvo-OrtizDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Catherine OrrVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Matthew D AlbaughVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Robert R AlthoffVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Kerry O'LoughlinVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Hannah HolbrookVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Hugh GaravanVermont Center for Children, Youth, and Families, Department of Psychiatry, University of Vermont, Burlington, VT, United States.
Bao-Zhu YangDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Stewart MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, United States; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, , United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Andrea JackowskiUniversidade Federal de São Paulo, São Paulo, Brazil.
Richard S LeeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Joel GelernterDepartment of Psychiatry, Yale University, New Haven, CT, United States; Veterans Administration, West Haven, CT, United States.
Joan KaufmanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States; Center for Child and Family Traumatic Stress, Kennedy Krieger Institute, Baltimore, MD, United States. Electronic address: joan.kaufman@kennedykrieger.org.
Kennedy Krieger Institute · USUniversity of Vermont · USCenter for Children · USYale University · USJohns Hopkins University · USUniversidade Federal de São Paulo · BR

Funding

RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
Risk and Resilience in Maltreated ChildrenR01MH098073 · NIMH · YALE UNIVERSITY · PI HUDZIAK, JAMES J., KAUFMAN, JOAN R. · 2012 to 2015
$3.0M
NIMH NIH HHS R01 MH098073NIMH NIH HHS T32 MH014276
6 · The paper itself

Abstract

The goal of the current study was to evaluate the impact of Tubulin Polymerization Promoting Protein (TPPP) methylation on structural and fractional anisotropy (FA) corpus callosum (CC) measures. TPPP is involved in the development of white matter tracts in the brain and was implicated in stress-related psychiatric disorders in an unbiased whole epigenome methylation study. The cohort included 63 participants (11.73 y/o ±1.91) from a larger study investigating risk and resilience in maltreated children. Voxel-based morphometry (VBM) was used to process the structural data, fractional anisotropy (FA) was determined using an atlas-based approach, and DNA specimens were derived from saliva in two batches using the 450 K (N = 39) and 850 K (N = 24) Illumina arrays, with the data from each batch analyzed separately. After controlling for multiple comparisons and relevant covariates (e.g., demographics, brain volume, cell composition, 3 PCs), 850 K derived TPPP methylation values, in interaction with a dimensional measure of children's trauma experiences, predicted left and right CC body volumes and genu, body and splenium FA (p < .007, all comparisons). The findings in the splenium replicated in subjects with the 450 K data. The results extend prior investigations and suggest a role for TPPP in brain changes associated with stress-related psychiatric disorders.

Indexed as

Child AbuseDNA MethylationAdolescentChildCohort StudiesCorpus CallosumFemaleHumansMagnetic Resonance ImagingMaleNerve Tissue ProteinsNerve Tissue ProteinsTPPP protein, human

Identifiers

PMID32120304
PMCPMC11079625
OpenAlexW3007947069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.