Evidence map›Paper›PMID 32120229›Full record

ArticleLung cancer (Amsterdam, Netherlands)2020

Stable and discriminating radiomic predictor of recurrence in early stage non-small cell lung cancer: Multi-site study.

Mohammadhadi Khorrami, Kaustav Bera, Patrick Leo, Pranjal Vaidya, Pradnya Patil, Rajat Thawani, Priya Velu, Prabhakar Rajiah, Mehdi Alilou, Humberto Choi and 7 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Lung cancer (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  5. [Advances in radiomics for early diagnosis and precision treatment of lung cancer].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Mohammadhadi KhorramiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Kaustav BeraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Patrick LeoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Pranjal VaidyaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Pradnya PatilDepartment of Solid Tumor Oncology, Cleveland Clinic, Cleveland, OH, USA.
Rajat ThawaniDepartment of Internal Medicine, Maimonides Medical Center, Brooklyn, NY, USA.
Priya VeluPathology and Laboratory Medicine, Hospital of the University of Pennsylvania, USA.
Prabhakar RajiahDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.
Mehdi AlilouDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Humberto ChoiDepartment of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, USA.
Michael D FeldmanPathology and Laboratory Medicine, Hospital of the University of Pennsylvania, USA.
Robert C GilkesonDepartment of Radiology, University Hospitals of Cleveland, OH, USA.
Philip LindenThoracic and Esophageal Surgery Department, University Hospitals of Cleveland, OH, USA.
Pingfu FuDepartment of Population and Quantitative Health Sciences, CWRU, Cleveland, OH, USA.
Harvey PassDepartment of Hematology and Oncology, NYU Langone Health, New York, NY, USA.
Vamsidhar VelchetiDepartment of Hematology and Oncology, NYU Langone Health, New York, NY, USA.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. Electronic address: anant.madabhushi@case.edu.
Case Western Reserve University · USCleveland Clinic · USHospital of the University of Pennsylvania · USNYU Langone Health · USUniversity Hospitals of Cleveland · USMaimonides Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
HistoTools: A suite of digital pathology tools for quality control, annotation and dataset identificationU01CA239055 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JANOWCZYK, ANDREW ROBERT, MADABHUSHI, ANANT · 2019 to 2022
$1.0M
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear SlidesR43EB028736 · NIBIB · DIASCOPIC, LLC · PI MADABHUSHI, ANANT, SERIF, CARY · 2019 to 2019
$225k
RadIO: A Novel Radiomics Toolkit to Predict and Characterize Response to Immunotherapy in Stage III Non-Small Cell Lung CancerI01BX004121 · VA · VETERANS HEALTH ADMINISTRATION · PI Anant Madabhushi, Charles J Nock · 2019 to 2026
–
BIOMEDICAL ENGINEERING RESEARCH FACILITIESC06RR012463 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI KUTINA, KENNETH L · 1997 to 1997
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BLRD VA I01 BX004121NCI NIH HHS R01 CA202752NCI NIH HHS R01 CA208236NCI NIH HHS R01 CA216579NCI NIH HHS R01 CA220581NCI NIH HHS U01 CA239055NCI NIH HHS U24 CA199374NCRR NIH HHS C06 RR012463NIBIB NIH HHS R43 EB028736
6 · The paper itself

Abstract

objectivesTo evaluate whether combining stability and discriminability criteria in building radiomic classifiers will improve the prognosis of cancer recurrence in early stage non-small cell lung cancer on non-contrast computer tomography (CT). MATERIALS AND

methodsCT scans of 610 patients with early stage (IA, IB, IIA) NSCLC from four independent cohorts were evaluated. A total of 350 patients from Cleveland Clinic Foundation and University of Pennsylvania were divided into two equal sets for training (D

resultsA feature selection strategy focusing on both feature discriminability and stability resulted in the classifier having a higher discriminability on validation datasets compared to the discriminability alone criteria in discriminating cancer recurrence (D

conclusionAccounting for both stability and discriminability yielded a more generalizable classifier for predicting cancer recurrence and TTP in early stage NSCLC.

Indexed as

Adenocarcinoma of LungAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalPneumonectomyPrognosisRetrospective StudiesAdjuvant chemotherapyNSCLCQuantitative imagingRadiomicsSurgery

Identifiers

PMID32120229
PMCPMC7141152
OpenAlexW3008157799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.