ArticleJournal of the American Academy of Child and Adolescent Psychiatry2021
Amygdala Functional Connectivity Is Associated With Emotion Regulation and Amygdala Reactivity in 4- to 6-Year-Olds.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Early maternal depressive symptoms and child developmental outcomes at six years old: a prospective birth cohort study in a low-risk population.World journal of pediatrics : WJP · 2026Article
- Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice.Molecular brain · 2026Article
- A Digital Tool for Assessing the Distinct Effects of Depression, Anxiety, and Attention-Deficit/Hyperactivity Disorder (ADHD) on Children's Emotional Cognitive Bias: Cross-Sectional Study.Journal of medical Internet research · 2026Article
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- The effects of adverse life events on brain development in the ABCD study®: a propensity-weighted analysis.Molecular psychiatry · 2025Article
- Dimensions of Depressive Symptoms in Young Children: Factor Analysis of the Preschool Feelings Checklist-Scale.Assessment · 2025Article
- Machine learning-based assessment of morphometric abnormalities distinguishes bipolar disorder and major depressive disorder.Neuroradiology · 2025Article
- Reduced recruitment of inhibitory control regions in very young children with ADHD during a modified Kiddie Continuous Performance Task: A fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD.BMC psychiatry · 2025Article
- The Effects of Adverse Life Events on Brain Development in the ABCD StudymedRxiv : the preprint server for health sciences · 2024Article
- Socioeconomic factors, sleep timing and duration, and amygdala resting-state functional connectivity in children.Frontiers in psychiatry · 2024Article
- Functional connectivity changes between amygdala and prefrontal cortex after ECT are associated with improvement in distinct depressive symptoms.European archives of psychiatry and clinical neuroscience · 2023Article
- Fetal Frontolimbic Connectivity Prospectively Associates With Aggression in Toddlers.Biological psychiatry global open science · 2023Article
- Somatovisceral influences on emotional development.Emotion review : journal of the International Society for Research on Emotion · 2023Article
- Keeping up with the kids: the value of co-production in the study of irritability in youth depression and its underlying neural circuitry.Frontiers in behavioral neuroscience · 2023Review
- Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity.Psychoradiology · 2023Article
- Prenatal Maternal Distress During the COVID-19 Pandemic and Associations With Infant Brain Connectivity.Biological psychiatry · 2022Article
- Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior.Social cognitive and affective neuroscience · 2022Article
- Tools to Address Children's Mental Health.Focus (American Psychiatric Publishing) · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveEmotion dysregulation has been suggested to be a potent risk factor for multiple psychiatric conditions. Altered amygdala-prefrontal cortex (PFC) connectivity has been consistently linked to emotion dysregulation. Recent data indicate that amygdala-PFC functional connectivity undergoes a prolonged period of development, with amygdala reactivity during early childhood potentially shaping this unfolding process. Little is known about the relationships between amygdala-PFC functional connectivity, amygdala reactivity, and emotion regulation during early childhood. This information is likely critical for understanding early emotion dysregulation as a transdiagnostic risk factor for psychopathology. The current study examined the relationships between amygdala functional connectivity, amygdala reactivity, and emotion regulation in preschoolers.
methodA total of 66 medication-naive 4- to 6-year-olds participated in a study where resting-state functional magnetic resonance imaging (rs-fMRI) and parent-reported child emotion regulation ability data were collected. fMRI data collected during a face viewing task was also available for 24 children.
resultsRight amygdala-medial PFC (mPFC) functional connectivity was positively associated with child emotion regulation ability and negatively associated with child negative affect and right amygdala reactivity to facial expressions of emotion. Right amygdala-mPFC functional connectivity also statistically mediated the relationship between heightened right amygdala reactivity and elevated child negative affect.
conclusionStudy findings suggest that amygdala-mPFC functional connectivity during early childhood, and its relationships with amygdala reactivity and emotion regulation during this highly sensitive developmental period, may play an important role in early emotional development. These results inform the neurodevelopmental biology of emotion regulation and its potential relationship with risk for psychopathology.
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