SynthesisInternational wound journal2020
Efficacy of topical silicone gel in scar management: A systematic review and meta-analysis of randomised controlled trials.
Synthesis in International wound journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- [Practice guideline for adult burn rehabilitation nursing (2026 edition)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Guideline
- Effect of Laser and Energy-based Device Therapies to Minimize Surgical Scar Formation: A Systematic Review and Network Meta-analysis.Acta dermato-venereologica · 2024Pooled it
- Onion extract gel is not better than other topical treatments in scar management: A meta-analysis from randomised controlled trails.International wound journal · 2021Pooled it
- Efficacy of topical silicone gel in scar management: A systematic review and meta-analysis of randomised controlled trials.International wound journal · 2020Pooled it
- Within-Patient, Evaluator-Blinded, Randomized Controlled Clinical Trial to Assess the Efficacy of Gel Sheets in the Treatment of Hypertrophic Scar in Adult Burn Survivors.Journal of burn care & research : official publication of the American Burn Association · 2026Trial
- Silicone gel versus combination of silicone gel and a 577-nm diode laser in the treatment of post-surgery hypertrophic scar (comparative study).Archives of dermatological research · 2025Trial
- Efficacy of Topical Losartan in Management of Mammoplasty and Abdominoplasty Scars: A Randomized, Double-Blind Clinical Trial.Aesthetic plastic surgery · 2022Trial
- Efficacy and Safety of Silicone Gel Plus Laser Therapy for Scar: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2026Article
- Assessing Patient Priorities and Satisfaction Regarding Aesthetic Outcomes Following Autologous Breast Reconstruction.Aesthetic plastic surgery · 2026Article
- Early multimodal treatment of post-traumatic facial scarring: A case report.SAGE open medical case reports · 2026Article
- Effectiveness of different non-surgical scar reduction methods in post-operative scars: a systematic review and meta-analysis.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2026Article
- Pirfenidone in Skin Fibrosis and Scarring: From Bench Insights to Clinical Data.Medical sciences (Basel, Switzerland) · 2025Review
- Review
- Comparative Evaluation of Postoperative Scarring with Nasolabial Flap Reconstruction Using Silicone Gel Versus Silicone Gel Sheet: Randomized Controlled Trial.Journal of maxillofacial and oral surgery · 2025Article
- The Pathophysiology and Management of Pathologic Scarring-a Contemporary Review.Advances in wound care · 2025Review
- Patient-Reported Dissatisfaction After Lip Lift: Insights From a Thematic Analysis of RealSelf Reviews.Aesthetic surgery journal. Open forum · 2025Review
- Keloid and Hypertrophic Scars Treatment.Aesthetic plastic surgery · 2024Article
- [Research advances on pharmacological interventions for hypertrophic scar].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Silicon-Based Scaffold for Wound Healing Skin Regeneration Applications: A Concise Review.Polymers · 2022Review
- Topical silicone gel mistaken for a retained orbital foreign body on MRI.BMJ case reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To assess the efficacy of topical silicone gel in the management of scars, we conducted this meta-analysis. The systematic search was performed on PubMed, Web of Science and Embase, and six randomised controlled trials with a total of 375 patients were involved. The outcome data of Vancouver Scar Scale were extracted from the studies and their effect sizes were calculated using Review Manager 5.3. As a result, topical silicone gel significantly reduced pigmentation, height, and pliability scores postoperatively compared with placebos or no treatment (Pigmentation: standard mean difference [SMD] = -0.55 [-0.83 to -0.26], P = .0002; Height: SMD = -0.73 [-1.02 to -0.44], P < .00001; Pliability: SMD = -0.49 [-0.95 to -0.03], P = .04). Topical silicone gel and silicone gel sheet were comparably effective (P > .05). The performance of topical silicone gel and other non-silicone topical treatment was also similar (P > .05). In summary, topical silicone gel was effective in post-operative scar prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.